C
Cornelis P. Vlaar
Researcher at University of Puerto Rico, Medical Sciences Campus
Publications - 22
Citations - 455
Cornelis P. Vlaar is an academic researcher from University of Puerto Rico, Medical Sciences Campus. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 6, co-authored 16 publications receiving 376 citations. Previous affiliations of Cornelis P. Vlaar include University of Puerto Rico.
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Journal ArticleDOI
Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase
Brenda L. Montalvo-Ortiz,Linette Castillo-Pichardo,Eliud Hernandez,Tessa Humphries-Bickley,Alina De La Mota-Peynado,Luis A. Cubano,Cornelis P. Vlaar,Suranganie Dharmawardhane +7 more
TL;DR: It is demonstrated that EHop-016 inhibits Rac activity in the MDA-MB-435 metastatic cancer cells that overexpress Rac and exhibits high endogenous Rac activity, and holds promise as a targeted therapeutic agent for the treatment of metastatic cancers with high Rac activity.
Journal ArticleDOI
The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model
Linette Castillo-Pichardo,Linette Castillo-Pichardo,Tessa Humphries-Bickley,Columba de la Parra,Ingrid Forestier-Roman,Magaly Martínez-Ferrer,Eliud Hernandez,Cornelis P. Vlaar,Yancy Ferrer-Acosta,Anthony V Washington,Luis A. Cubano,José F. Rodríguez-Orengo,Suranganie Dharmawardhane +12 more
TL;DR: EHop-016 has potential as an anticancer compound to block cancer progression via multiple Rac-directed mechanisms and affected cell viability by down-regulating Akt and Jun kinase activities and c-Myc and Cyclin D expression, as well as increasing caspase 3/7 activities in metastatic cancer cells.
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Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer
Tessa Humphries-Bickley,Linette Castillo-Pichardo,Linette Castillo-Pichardo,Eliud Hernandez-O'Farrill,Luis D. Borrero-Garcia,Ingrid Forestier-Roman,Yamil Gerena,Manuel Blanco,Michael John Rivera-Robles,José R. Rodríguez-Medina,Luis A. Cubano,Cornelis P. Vlaar,Suranganie Dharmawardhane +12 more
TL;DR: MBQ-167 is 10× more potent than other currently available Rac/Cdc42 inhibitors and has the potential to be developed as an anticancer drug, as well as a dual inhibitory probe for the study of Rac and Cdc42.
Journal ArticleDOI
Synthesis of 1,4-dihydro-benzo[d][1,3]oxazin-2-ones from phthalides via an aminolysis-Hofmann rearrangement protocol
TL;DR: A simple two-step procedure for the conversion of readily available phthalides to the corresponding benzoxazinones was developed and conveniently provided a variety of 4-substituted benzoxzinones.
Journal ArticleDOI
Pak and Rac GTPases promote oncogenic KIT–induced neoplasms
Holly Martin,Raghuveer Singh Mali,Peilin Ma,Anindya Chatterjee,Baskar Ramdas,Emily K. Sims,Veerendra Munugalavadla,Joydeep Ghosh,Ray R. Mattingly,Valeria Visconte,Ramon V. Tiu,Cornelis P. Vlaar,Suranganie Dharmawardhane,Reuben Kapur +13 more
TL;DR: Pak and Rac GTPases, including Vav1, are identified as potential therapeutic targets in MPN and AML involving an oncogenic form of KIT.