R
Reuben Kapur
Researcher at Indiana University
Publications - 203
Citations - 7003
Reuben Kapur is an academic researcher from Indiana University. The author has contributed to research in topics: Haematopoiesis & Progenitor cell. The author has an hindex of 43, co-authored 185 publications receiving 5988 citations. Previous affiliations of Reuben Kapur include Indiana University – Purdue University Indianapolis & University of Tokyo.
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Journal ArticleDOI
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
Anubhav N. Mathur,Hua Chen Chang,Dimitrios G. Zisoulis,Gretta L. Stritesky,Qing Yu,John T. O'Malley,Reuben Kapur,David E. Levy,Geoffrey S. Kansas,Mark H. Kaplan +9 more
TL;DR: It is demonstrated that Stat3 is required for programming the TGFβ1 plus IL-6 and IL-23-stimulated IL-17-secreting phenotype, as well as for RORγt expression in TGF β1 plusIL-6-primed cells.
Journal ArticleDOI
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Charlie Mantel,Heather O'Leary,Brahmananda R. Chitteti,Xinxin Huang,Scott Cooper,Giao Hangoc,Nickolay Brustovetsky,Edward F. Srour,Man Ryul Lee,Man Ryul Lee,Steve Messina-Graham,David M. Haas,Nadia Falah,Reuben Kapur,Louis M. Pelus,Nabeel Bardeesy,Julien Fitamant,Mircea Ivan,Kye Seong Kim,Hal E. Broxmeyer +19 more
TL;DR: In this article, the extraphysiologic oxygen shock/stress (EPHOSS) phenomenon was found to decrease the recovery of long-term repopulating HSCs and increase progenitor cells.
Journal ArticleDOI
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
Zhigang Cai,Jonathan J. Kotzin,Baskar Ramdas,Sisi Chen,Sai Nelanuthala,Lakshmi Reddy Palam,Ruchi Pandey,Raghuveer Singh Mali,Yan Liu,Mark R. Kelley,George E. Sandusky,Morvarid Mohseni,Adam Williams,Jorge Henao-Mejia,Reuben Kapur +14 more
TL;DR: A rapid increase in the frequency and absolute number of Tet2-KO mature myeloid cells and HSPCs in response to inflammatory stress is shown, which results in enhanced production of inflammatory cytokines, including interleukin-6 (IL-6), and resistance to apoptosis.
Journal ArticleDOI
Neurofibromin-deficient Schwann cells secrete a potent migratory stimulus for Nf1+/– mast cells
Feng Chun Yang,David A. Ingram,Shi Chen,Cynthia M. Hingtgen,Nancy Ratner,Kelly R. Monk,Travis Clegg,Hilary White,Laura E. Mead,Mary Jo Wenning,David R. Williams,Reuben Kapur,Simon J. Atkinson,D. Wade Clapp +13 more
TL;DR: It is shown that homozygous Nf1 mutant (Nf1-/-) Schwann cells secrete Kit ligand (KitL), which stimulates mast cell migration, and that N f1+/- mast cells are hypermotile in response to KitL, which links hyperactivation of the Ras-class IA-PI3K-Rac2 pathway to increased Nf 1+/-mast cell migration.
Journal ArticleDOI
Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells.
Feng Chun Yang,Reuben Kapur,Alastair J. King,Wen Tao,Chaekyun Kim,Jovencio Borneo,Robert Breese,Mark S. Marshall,Mary C. Dinauer,David R. Williams +9 more
TL;DR: It is suggested that Rac2 plays a unique role in multiple cellular functions and an essential role for Rac2 in growth factor-dependent survival and expression of BAD/Bcl-XL is described.