Corrina L. Hale

TL;DR: The development and use of replication-competent and replication-defective strains of recombinant herpes simplex virus that express envelope and Nef antigens of simian immunodeficiency virus (SIV) show great promise for being able to elicit persistent immune responses and to provide durable protection against AIDS.

TL;DR: The frequency of cytomegalovirus (CMV)-specific CD4+ T lymphocytes was determined in CMV-seropositive rhesus macaques with or without simian immunodeficiency virus (SIV) infection by using the sensitive assays of intracellular cytokine staining and gamma interferon ELISPOT to facilitate the study of CMV pathogenesis in AIDS.

TL;DR: Divergent patterns of proliferation and activation are exhibited by CD4+ and CD8+ T lymphocytes in early SIV infection and may determine how these cells are differentially affected in AIDS.

TL;DR: The occurrence of CMV reactivation-associated disease in AIDS is associated with suppression of both cellular and humoral CMV-specific immune responses, and the underlying mechanism may be a dysfunction of memory B and CD8+ T lymphocytes associated with SIV-induced impairment of CMv-specific CD4+ T-cell help.

TL;DR: The occurrence of CTL escape in a host that does not develop AIDS is recorded, and adds to the growing body of evidence that CTL exert significant selective pressure in SIV infection.