C
Costas D. Arvanitis
Researcher at Georgia Institute of Technology
Publications - 71
Citations - 3202
Costas D. Arvanitis is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Microbubbles & Ultrasound. The author has an hindex of 22, co-authored 65 publications receiving 2244 citations. Previous affiliations of Costas D. Arvanitis include University of Oxford & Brigham and Women's Hospital.
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Journal ArticleDOI
The blood–brain barrier and blood–tumour barrier in brain tumours and metastases
TL;DR: A deeper understanding of the BBB and BTB through the application of single-cell sequencing and imaging techniques, and the development of biomarkers of BBB integrity along with systems biology approaches, should enable new personalized treatment strategies for primary brain malignancies and brain metastases.
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Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques
TL;DR: The findings show that BBB disruption can be reliably and repeatedly produced without evident histologic or functional damage in a clinically relevant animal model using a clinical device, and support clinical testing of this noninvasive-targeted drug delivery method.
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Ultrasound-mediated blood–brain barrier disruption for targeted drug delivery in the central nervous system
TL;DR: Focused ultrasound (FUS), when combined with circulating microbubbles, is a noninvasive method to locally and transiently disrupt the blood-brain barrier at discrete targets and would offer a flexible means to target therapeutics to desired points or volumes in the brain.
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Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring
TL;DR: The results indicate that harmonic emissions can be a used to control focused ultrasound-induced BBB disruption and are promising for clinical translation of this technology.
Journal ArticleDOI
Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption.
Costas D. Arvanitis,Vasileios Askoxylakis,Yutong Guo,Meenal Datta,Meenal Datta,Jonas Kloepper,Gino B. Ferraro,Miguel O. Bernabeu,Dai Fukumura,Nathan McDannold,Rakesh K. Jain +10 more
TL;DR: It is demonstrated that focused ultrasound-induced BBB/BTB disruption contributes to enhanced interstitial convective transport in solid tumors, in addition to alleviating vascular barriers, and evidence of improved penetration of nontargeted and antibody-targeted chemotherapies is provided.