M
Miguel O. Bernabeu
Researcher at University of Edinburgh
Publications - 105
Citations - 3174
Miguel O. Bernabeu is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 23, co-authored 81 publications receiving 2600 citations. Previous affiliations of Miguel O. Bernabeu include University College London & University of Oxford.
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Journal ArticleDOI
Chaste: an open source C++ library for computational physiology and biology.
Gary R. Mirams,Christopher J. Arthurs,Miguel O. Bernabeu,Rafel Bordas,Jonathan Cooper,Alberto Corrias,Yohan Davit,Sara-Jane Dunn,Alexander G. Fletcher,Daniel G. Harvey,Megan E. Marsh,James M. Osborne,Pras Pathmanathan,Pras Pathmanathan,Joe Pitt-Francis,James Southern,Nejib Zemzemi,David J. Gavaghan +17 more
TL;DR: Chaste as mentioned in this paper is an open source C++ library for the computational simulation of mathematical models developed for physiology and biology, such as cardiac electrophysiology and cancer development, which can be used to solve a wide range of problems.
Journal ArticleDOI
Chaste: A test-driven approach to software development for biological modelling☆
Joe Pitt-Francis,Pras Pathmanathan,Miguel O. Bernabeu,Rafel Bordas,Jonathan Cooper,Alexander G. Fletcher,Gary R. Mirams,Philip J. Murray,James M. Osborne,Alex Walter,S. Jonathan Chapman,Alan Garny,Ingeborg M.M. van Leeuwen,Philip K. Maini,Blanca Rodriguez,Sarah L. Waters,Jonathan P. Whiteley,Helen M. Byrne,David J. Gavaghan +18 more
TL;DR: Chaste (‘Cancer, heart and soft-tissue environment’) is a software library and a set of test suites for computational simulations in the domain of biology and has been developed using agile programming methods.
Journal ArticleDOI
Dynamic endothelial cell rearrangements drive developmental vessel regression.
Claudio A. Franco,Martin L. Jones,Miguel O. Bernabeu,Ilse Geudens,Thomas Mathivet,Andre Rosa,Felicia M. Lopes,Aida P. Lima,Anan Ragab,Russell T. Collins,Li-Kun Phng,Peter V. Coveney,Holger Gerhardt +12 more
TL;DR: It is proposed that balanced movement of cells maintains the primitive plexus under low shear conditions in a metastable dynamic state and predicted that flow-induced polarized migration of endothelial cells breaks symmetry and leads to stabilization of high flow/ shear segments and regression of adjacent low flow/shear segments.
Journal ArticleDOI
Verification of cardiac tissue electrophysiology simulators using an N-version benchmark
Steven A. Niederer,Eric Kerfoot,Alan P. Benson,Miguel O. Bernabeu,Olivier Bernus,Chris P. Bradley,Elizabeth M. Cherry,Richard H. Clayton,Flavio H. Fenton,Alan Garny,Elvio Heidenreich,Sander Land,Mary M. Maleckar,Pras Pathmanathan,Gernot Plank,Jose F. Rodriguez,Ishani Roy,Frank B. Sachse,Gunnar Seemann,Ola Skavhaug,Nic Smith +20 more
TL;DR: This study provides the first cardiac tissue electrophysiology simulation benchmark to allow these codes to be verified and was successfully evaluated on 11 simulation platforms to generate a consensus gold-standard converged solution.
Journal ArticleDOI
Generation of histo-anatomically representative models of the individual heart: tools and application
Gernot Plank,Gernot Plank,Rebecca A.B. Burton,Patrick W. Hales,Martin J. Bishop,Tahir Mansoori,Miguel O. Bernabeu,Alan Garny,Anton J. Prassl,Christian Bollensdorff,Fleur E. Mason,Fahd Mahmood,Blanca Rodriguez,Vicente Grau,Jürgen E. Schneider,David J. Gavaghan,Peter Kohl +16 more
TL;DR: This paper presents methods to build histo-anatomically detailed individualized cardiac models based on high-resolution three-dimensional anatomical and/or diffusion tensor magnetic resonance images, combined with serial histological sectioning data, and is used to investigate individualized heart function.