Courtney Coker

TL;DR: It is reported that local injection of CD47nb-expressing bacteria stimulates systemic tumor-antigen-specific immune responses that reduce the growth of untreated tumors, providing proof-of-concept for an abscopal effect induced by an engineered bacterial immunotherapy.

TL;DR: A single injection of this engineered system demonstrated an enhanced therapeutic response compared to analogous clinically relevant antibodies, resulting in tumor regression in syngeneic mouse models, demonstrating that the engineered probiotic system bridges synthetic biology and immunology to improve upon checkpoint blockade delivery.

TL;DR: It is shown that CIN in cultured cells lacking Rb family proteins requires Mad2 upregulation and that this upregulation is also necessary for CIN and tumor progression in vivo.

TL;DR: Using PDGF- and KRAS-driven murine models of gliomagenesis, it is shown that high Id1 expression (Id1(high)) identifies tumor cells with high self-renewal capacity, while low Id1expression ( Id1(low)); Surprisingly, Id1 (low) cells generate tumors more rapidly and with higher penetrance than Id 1(high) cells.

TL;DR: This work identifies the metal-ion transporter ZRT- and IRT-like protein 14 (ZIP14) as a critical mediator of cancer-induced cachexia and implicates ZIP14 as a therapeutic target for its treatment.