Rinku Jain

TL;DR: Hox proteins recognize specific Hox-Exd binding sites via residues located in these extended regions that insert into the minor groove but only when presented with the correct DNA sequence, suggesting that these residues confer specificity by recognizing a sequence-dependent DNA structure instead of directly reading a specific DNA sequence.

TL;DR: The structures reveal that the ability of Polη to replicate efficiently through the ultraviolet-induced lesion derives from a simple and yet elegant mechanism, wherein the two Ts of the T-T dimer are accommodated in an active site cleft that is much more open than in other polymerases.

TL;DR: This review describes the mechanisms that each class of heme protein sensor and transporter utilizes to promote this discrimination against other heme ligands of similar size and shape.

TL;DR: This work identifies the metal-ion transporter ZRT- and IRT-like protein 14 (ZIP14) as a critical mediator of cancer-induced cachexia and implicates ZIP14 as a therapeutic target for its treatment.

TL;DR: This work presents a high-resolution crystal structure of the RNA helicase from the French Polynesia strain, and identifies druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.