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Courtney M. Mazur
Researcher at University of California, San Francisco
Publications - 18
Citations - 371
Courtney M. Mazur is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Osteocyte & Cartilage. The author has an hindex of 7, co-authored 16 publications receiving 242 citations. Previous affiliations of Courtney M. Mazur include Dartmouth College & University of California, Berkeley.
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Journal ArticleDOI
Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling.
Neha S. Dole,Courtney M. Mazur,Claire Acevedo,Justin P. Lopez,Justin P. Lopez,David A. Monteiro,David A. Monteiro,Tristan W. Fowler,Bernd Gludovatz,Flynn Walsh,Jenna N. Regan,Sara A. Messina,Daniel S. Evans,Thomas Lang,Bin Zhang,Robert O. Ritchie,Robert O. Ritchie,Khalid S. Mohammad,Tamara Alliston,Tamara Alliston +19 more
TL;DR: It is shown that TGF-β regulates PLR in a cell-intrinsic manner to control bone quality and emphasized that osteocytes are key in executing the biological control of bone quality through PLR, thereby highlighting the fundamental role of osteocyte-mediatedPLR in bone homeostasis and fragility.
Journal ArticleDOI
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis
Tristan W. Fowler,Claire Acevedo,Claire Acevedo,Courtney M. Mazur,Courtney M. Mazur,Faith Hall-Glenn,Aaron J. Fields,Hrishikesh Bale,Robert O. Ritchie,Robert O. Ritchie,Jeffrey C. Lotz,Jeffrey C. Lotz,Thomas P. Vail,Tamara Alliston,Tamara Alliston +14 more
TL;DR: In this article, osteocyte-driven perilacunar remodeling, a fundamental cellular mechanism, plays a critical role in the glucocorticoid-induced osteonecrosis.
Journal ArticleDOI
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis
Courtney M. Mazur,Jonathon J. Woo,Cristal S. Yee,Aaron J. Fields,Claire Acevedo,Claire Acevedo,Karsyn N. Bailey,Karsyn N. Bailey,Serra Kaya,Tristan W. Fowler,Jeffrey C. Lotz,Jeffrey C. Lotz,Alexis Dang,Alexis Dang,Alfred C. Kuo,Alfred C. Kuo,Thomas P. Vail,Tamara Alliston,Tamara Alliston +18 more
TL;DR: Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis, likely via its effects on PLR, and suggests a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis.
Journal ArticleDOI
Effects of Chondroitinase ABC-Mediated Proteoglycan Digestion on Decellularization and Recellularization of Articular Cartilage.
TL;DR: ChABC treatment enhances decellularization of the relatively dense, impermeable articular cartilage by reducing glycosaminoglycan content, highlighting the need for more dynamic seeding methods.
Journal ArticleDOI
Glucocorticoids cause mandibular bone fragility and suppress osteocyte perilacunar-canalicular remodeling.
A. Sean Alemi,Courtney M. Mazur,Courtney M. Mazur,Tristan W. Fowler,Jonathon J. Woo,P. Daniel Knott,Tamara Alliston,Tamara Alliston +7 more
TL;DR: Osteocyte PLR in the neural crest-derived mandible is susceptible to glucocorticoids, just as it is in the mesodermally-derived femur, highlighting the need to further study PLR as a target of drugs, and radiation in mandibular osteonecrosis.