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Claire Acevedo
Researcher at University of Utah
Publications - 43
Citations - 869
Claire Acevedo is an academic researcher from University of Utah. The author has contributed to research in topics: Residual stress & Osteocyte. The author has an hindex of 15, co-authored 34 publications receiving 616 citations. Previous affiliations of Claire Acevedo include Lawrence Berkeley National Laboratory & University of California, San Francisco.
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Journal ArticleDOI
Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling.
Neha S. Dole,Courtney M. Mazur,Claire Acevedo,Justin P. Lopez,Justin P. Lopez,David A. Monteiro,David A. Monteiro,Tristan W. Fowler,Bernd Gludovatz,Flynn Walsh,Jenna N. Regan,Sara A. Messina,Daniel S. Evans,Thomas Lang,Bin Zhang,Robert O. Ritchie,Robert O. Ritchie,Khalid S. Mohammad,Tamara Alliston,Tamara Alliston +19 more
TL;DR: It is shown that TGF-β regulates PLR in a cell-intrinsic manner to control bone quality and emphasized that osteocytes are key in executing the biological control of bone quality through PLR, thereby highlighting the fundamental role of osteocyte-mediatedPLR in bone homeostasis and fragility.
Journal ArticleDOI
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis
Tristan W. Fowler,Claire Acevedo,Claire Acevedo,Courtney M. Mazur,Courtney M. Mazur,Faith Hall-Glenn,Aaron J. Fields,Hrishikesh Bale,Robert O. Ritchie,Robert O. Ritchie,Jeffrey C. Lotz,Jeffrey C. Lotz,Thomas P. Vail,Tamara Alliston,Tamara Alliston +14 more
TL;DR: In this article, osteocyte-driven perilacunar remodeling, a fundamental cellular mechanism, plays a critical role in the glucocorticoid-induced osteonecrosis.
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Intrinsic mechanical behavior of femoral cortical bone in young, osteoporotic and bisphosphonate-treated individuals in low- and high energy fracture conditions
Elizabeth A. Zimmermann,Eric Schaible,Bernd Gludovatz,Felix N. Schmidt,Christoph Riedel,Matthias Krause,Eik Vettorazzi,Claire Acevedo,Michael Hahn,Klaus Püschel,Simon Y. Tang,Michael Amling,Robert O. Ritchie,Robert O. Ritchie,Björn Busse,Björn Busse +15 more
TL;DR: Loss in strength and fibril deformation at low strain rates correlate with the occurrence of fragility fractures in osteoporosis, while improvements in structural and mechanical properties following bisphosphonate treatment may foster resistance to fracture during physiological strain rates.
Journal ArticleDOI
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis
Courtney M. Mazur,Jonathon J. Woo,Cristal S. Yee,Aaron J. Fields,Claire Acevedo,Claire Acevedo,Karsyn N. Bailey,Karsyn N. Bailey,Serra Kaya,Tristan W. Fowler,Jeffrey C. Lotz,Jeffrey C. Lotz,Alexis Dang,Alexis Dang,Alfred C. Kuo,Alfred C. Kuo,Thomas P. Vail,Tamara Alliston,Tamara Alliston +18 more
TL;DR: Osteocyte-derived MMP13 emerges as a critical regulator of cartilage homeostasis, likely via its effects on PLR, and suggests a causal role for suppressed perilacunar/canalicular remodeling in osteoarthritis.
Journal ArticleDOI
Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone.
Claire Acevedo,Hrishikesh Bale,Bernd Gludovatz,Amy Wat,Simon Y. Tang,Mingyue Wang,Björn Busse,Elizabeth A. Zimmermann,Eric Schaible,Matthew R. Allen,David B. Burr,Robert O. Ritchie,Robert O. Ritchie +12 more
TL;DR: It is hypothesized that the reduced plasticity associated with bisphosphonate treatments may induce an increase in microcrack accumulation and growth under cyclic daily loadings, and potentially increase the susceptibility of cortical bone to atypical (fatigue-like) fractures.