Craig R. Fairchild

TL;DR: Efficacy data demonstrate that BMS-247550 has the potential to surpass Taxol in both clinical efficacy and ease of use (i.e., less frequent treatment schedule and/or oral administration).

TL;DR: Comparison of paired specimens from the same patient indicated that GST pi expression was increased in many tumors relative to matched normal tissue, and while the human anionic GST displays 85% nucleotide and amino acid sequence homology to the rat anionic isozyme, it is markedly less related to human basic GST isozymes.

TL;DR: It is implicate that dasatinib may represent a valuable treatment option in this difficult-to-treat population of patients with resistance or intolerance to prior therapy and to test this hypothesis, clinical studies are under way to determine the activity of d asatinib in these patients.

TL;DR: In situ hybridization studies demonstrated that the human P-glycoprotein gene sequence was found on chromosome 7q21.1 in normal human lymphocytes and that amplified DNA sequences isolated from the Adriamycin-resistant MCF-7 cells by the in-gel hybridization technique were linked to thehuman P- glycoprotein sequences in the homogeneously staining regions in the AdrR cells.