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Xia Han
Researcher at Bristol-Myers Squibb
Publications - 9
Citations - 1403
Xia Han is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Tyrosine kinase & Receptor tyrosine kinase. The author has an hindex of 6, co-authored 9 publications receiving 1353 citations.
Papers
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Journal ArticleDOI
Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts.
Yudi Pawitan,Judith Bjöhle,Lukas C. Amler,Anna-Lena Borg,Suzanne Egyhazi,Per Hall,Xia Han,Lars Holmberg,Fei Huang,Sigrid Klaar,Edison T. Liu,Lance D. Miller,Hans Nordgren,Alexander Ploner,Kerstin Sandelin,Peter M. Shaw,Johanna Smeds,Lambert Skoog,Sara Wedrén,Jonas Bergh +19 more
TL;DR: A subset of 64 genes was found to give an optimal separation of patients with good and poor outcomes, and the signature associated with prognosis and impact of adjuvant therapies was identified.
Journal ArticleDOI
Identification of Candidate Molecular Markers Predicting Sensitivity in Solid Tumors to Dasatinib: Rationale for Patient Selection
Fei Huang,Karen A. Reeves,Xia Han,Craig R. Fairchild,Suso Platero,Tai W. Wong,Francis Y.F. Lee,Peter E. Shaw,Edwin A. Clark +8 more
TL;DR: It is implicate that dasatinib may represent a valuable treatment option in this difficult-to-treat population of patients with resistance or intolerance to prior therapy and to test this hypothesis, clinical studies are under way to determine the activity of d asatinib in these patients.
Journal ArticleDOI
Colorectal cancers with microsatellite instability display mRNA expression signatures characteristic of increased immunogenicity
Ayan Banerjea,Shafi Ahmed,Rebecca Hands,Fei Huang,Xia Han,Peter M. Shaw,Roger Feakins,Stephen A. Bustin,Sina Dorudi +8 more
TL;DR: The upregulation of a large number of genes implicated in immune response supports the theory that colorectal cancers displaying high-degree microsatellite instability are immunogenic.
Patent
Polynucleotide predictor set for identifying protein tyrosine kinase modulators
Lucas Amler,Craig R. Fairchild,Xia Han,Fei Huang,Francis Y. Lee,Karen A. Reeves,Peter E. Shaw +6 more
TL;DR: In this paper, the authors describe polynucleotides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn.
Patent
Identification of polynucleotides for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
Fei Huang,Xia Han,Karen A. Reeves,Lukas C. Amler,Craig R. Fairchild,Francis Y. Lee,Peter M. Shaw +6 more
TL;DR: In this article, the authors describe polynucleotides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn.