Craig W. Berridge

TL;DR: It is suggested that dysregulation of locus coeruleus-noradrenergic neurotransmission may contribute to cognitive and/or arousal dysfunction associated with a variety of psychiatric disorders, including attention-deficit hyperactivity disorder, sleep and arousal disorders, as well as certain affective Disorders, including post-traumatic stress disorder.

TL;DR: The cerebral distribution of CRF and binding sites for CRF is described in detail in the second part of this report, which aims to establish a baseline for the distribution of these sites in the brain.

TL;DR: At low doses that improve PFC-dependent cognitive function and that are devoid of locomotor-activating effects, MPH substantially increases NE and DA efflux within the PFC.

TL;DR: Observations indicate that enhanced LC discharge activity is the crucial mediating event for the infusion-induced changes in forebrain EEG activity observed under these conditions and suggest that LC activation may be sufficient to induce EEG signs of cortical and hippocampal activation.

TL;DR: Investigation of overlap between dopamine‐β‐hydroxylase (DβH) ‐immunopositive projections and the projections of hypothalamic neurons containing the arousal‐ and feeding‐related peptide, orexin/hypocretin (HCRT), in rat brain found the projections jointly target several forebrain regions and brainstem monoaminergic nuclei involved in regulating core motivational processes.