C
Cristian A. Lasagna-Reeves
Researcher at Indiana University
Publications - 50
Citations - 4294
Cristian A. Lasagna-Reeves is an academic researcher from Indiana University. The author has contributed to research in topics: Amyloid & Medicine. The author has an hindex of 23, co-authored 41 publications receiving 3532 citations. Previous affiliations of Cristian A. Lasagna-Reeves include Baylor College of Medicine & University of Texas Medical Branch.
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Journal ArticleDOI
Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice.
Cristian A. Lasagna-Reeves,Dennisse Gonzalez-Romero,Dennisse Gonzalez-Romero,Marcelo A. Barria,Marcelo A. Barria,Ivonne Olmedo,Ivonne Olmedo,Audra L. Clos,V. M. Sadagopa Ramanujam,Akihiko Urayama,Akihiko Urayama,L. Vergara,Marcelo J. Kogan,Claudio Soto,Claudio Soto +14 more
TL;DR: The data suggest that GNPs are able to cross the blood-brain barrier and accumulate in the neural tissue, and the accumulation of the particles does not produce sub-acute physiological damage.
Journal ArticleDOI
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
Cristian A. Lasagna-Reeves,Diana L. Castillo-Carranza,Urmi Sengupta,Audra L. Clos,George R. Jackson,Rakez Kayed +5 more
TL;DR: It is reported that oligomers of recombinant full-length human tau protein are neurotoxic in vivo after subcortical stereotaxic injection into mice, and suggests that tau oligomers induce neurodegeneration by affecting mitochondrial and synaptic function, both of which are early hallmarks in AD and other tauopathies.
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Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
Cristian A. Lasagna-Reeves,Diana L. Castillo-Carranza,Urmi Sengupta,José Sarmiento,José Sarmiento,Juan C. Troncoso,George R. Jackson,Rakez Kayed +7 more
TL;DR: A novel tau oligomer‐specific antibody is engineered and used to elucidate the temporal course and biochemical features of oligomers during NFT development in AD brain and highlight the suitability of tAU oligomers as therapeutic targets in AD and related tauopathies.
Journal ArticleDOI
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau.
Cristian A. Lasagna-Reeves,Diana L. Castillo-Carranza,Urmi Sengupta,Marcos J. Guerrero-Muñoz,Takaki Kiritoshi,Volker Neugebauer,George R. Jackson,Rakez Kayed +7 more
TL;DR: It is observed for the first time that these authentic brain-derived tau oligomers propagate abnormal tau conformation of endogenous murine tau after prolonged incubation.
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Molecular mechanisms of amyloid oligomers toxicity.
TL;DR: It is suggested that the complexity and dynamic nature of amyloid oligomers may be responsible for the discrepancy among these mechanisms and the proposed cellular targets for amyloids oligomers.