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Cristiana Fè d'Ostiani
Researcher at University of Perugia
Publications - 10
Citations - 1603
Cristiana Fè d'Ostiani is an academic researcher from University of Perugia. The author has contributed to research in topics: Candida albicans & Immune system. The author has an hindex of 9, co-authored 10 publications receiving 1568 citations.
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Journal ArticleDOI
Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans Implications for Initiation of T Helper Cell Immunity in Vitro and in Vivo
Cristiana Fè d'Ostiani,Giuseppe Del Sero,Angela Bacci,Claudia Montagnoli,Antonio Spreca,Antonella Mencacci,Paola Ricciardi-Castagnoli,Luigina Romani +7 more
TL;DR: By the discriminative production of IL-12 and IL-4 in response to the nonvirulent and virulent forms of the fungus, dendritic cells appear to meet the challenge of Th priming and education in C. albicans saprophytism and infections.
Journal ArticleDOI
Cytokine- and T Helper-Dependent Lung Mucosal Immunity in Mice with Invasive Pulmonary Aspergillosis
Elio Cenci,Antonella Mencacci,Cristiana Fè d'Ostiani,Giuseppe Del Sero,Paolo Mosci,Claudia Montagnoli,Angela Bacci,Luigina Romani +7 more
TL;DR: Results indicate that, similar to observations in mice with disseminated aspergillosis, innate and Th1-dependent immunity play an essential role in host defense against IPA.
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Interleukin-4 Causes Susceptibility to Invasive Pulmonary Aspergillosis through Suppression of Protective Type I Responses
Elio Cenci,Antonella Mencacci,Giuseppe Del Sero,Angela Bacci,Claudia Montagnoli,Cristiana Fè d'Ostiani,Paolo Mosci,Martin F. Bachmann,Francesco Bistoni,Manfred Kopf,Luigina Romani +10 more
TL;DR: It is demonstrated that IL-4 renders mice susceptible to infection with A. fumigatus by inhibition of protective Th1 responses, which appears to have a distinct role in the pathogenesis of allergic and nonallergic lung diseases caused by the fungus.
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Iron Overload Alters Innate and T Helper Cell Responses to Candida albicans in Mice
Antonella Mencacci,Elio Cenci,Johan R. Boelaert,Paola Bucci,Paolo Mosci,Cristiana Fè d'Ostiani,Francesco Bistoni,Luigina Romani +7 more
TL;DR: Treatment of iron-overloaded mice with the iron chelator, deferoxamine, resulted in the cure of mice from infection, restored the antifungal effector and immunomodulatory functions of the phagocytic cells, and allowed the occurrence of CD4 Th1 protective antIFungal responses.
Journal ArticleDOI
Endogenous Interleukin 4 Is Required for Development of Protective CD4+ T Helper Type 1 Cell Responses to Candida albicans
Antonella Mencacci,Giuseppe Del Sero,Elio Cenci,Cristiana Fè d'Ostiani,Angela Bacci,Claudia Montagnoli,Manfred Kopf,Luigina Romani +7 more
TL;DR: Findings indicate that endogenous IL-4 is required for the induction of CD4+ Th1 protective antifungal responses, possibly through the combined activity on cells of the innate and adaptive immune systems.