C
Cristiana Valle
Researcher at National Research Council
Publications - 45
Citations - 1421
Cristiana Valle is an academic researcher from National Research Council. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Neurodegeneration. The author has an hindex of 20, co-authored 40 publications receiving 1149 citations.
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Oxidative stress and mitochondrial damage: importance in non-SOD1 ALS.
TL;DR: New evidence indicates that MD and OS play a role also in non-SOD1 ALS and thus they may represent a target for therapy despite previous failures in clinical trials.
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Mitochondria and ALS: implications from novel genes and pathways.
TL;DR: A brief update on mitochondrial function and dysfunction in neurodegeneration is provided in the light of newly discovered genes associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria.
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Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity
Alberto Ferri,Paolo Fiorenzo,Monica Nencini,Mauro Cozzolino,Maria Grazia Pesaresi,Cristiana Valle,Sara Sepe,Sandra Moreno,Maria Teresa Carrì +8 more
TL;DR: It is shown that the overexpression of Grx1 increases the solubility of mutant S OD1 in the cytosol but does not inhibit mitochondrial damage and apoptosis induced by mutant SOD1 in neuronal cells (SH-SY5Y) or in immortalized motoneurons (NSC-34).
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SIRT3 and mitochondrial metabolism in neurodegenerative diseases.
TL;DR: It is reported that expression of the mitochondrial isoform of SIRT3 is altered in muscle from the G93A‐SOD1 mice during progression of disease; this alteration influences mitochondrial metabolism, which may be relevant for the well known energetic alterations taking place in ALS patients.
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Genetic analysis of decreased praziquantel sensitivity in a laboratory strain of Schistosoma mansoni
Livia Pica-Mattoccia,Michael J. Doenhoff,Cristiana Valle,Annalisa Basso,Anna-Rita Troiani,Piero Liberti,Alfredo Festucci,Alessandra Guidi,Donato Cioli +8 more
TL;DR: It is concluded that hybrid schistosomes of the F(1) generation have a drug sensitivity intermediate between those of the two parental strains and are thus suggestive of a pattern of partial dominance for the trait under study.