Sandra Moreno

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is suggested that in the adult CNS, PPARs and RXRs, besides playing roles common to many other tissues, may have specific functions in regulating the expression of genes involved in neurotransmission, and therefore play roles in complex processes, such as aging, neurodegeneration, learning and memory.

TL;DR: This work finds a non-apoptotic baseline caspase-3 activity in hippocampal dendritic spines and an enhancement of this activity at the onset of memory decline in the Tg2576-APPswe mouse model of Alzheimer's disease, and identifies a previously unknown casp enzyme-3–dependent mechanism that drives synaptic failure and contributes to cognitive dysfunction in Alzheimer's Disease.

TL;DR: By crossing Huntington's disease R6/1 transgenic mice with ‘tissue’ transglutaminase (TG2) knock-out mice, it is demonstrated that this multifunctional enzyme plays an important role in the neuronal death characterising this disorder in vivo.