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Alfredo Festucci
Researcher at National Research Council
Publications - 6
Citations - 265
Alfredo Festucci is an academic researcher from National Research Council. The author has contributed to research in topics: Schistosoma mansoni & Peptide sequence. The author has an hindex of 5, co-authored 6 publications receiving 249 citations.
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Journal ArticleDOI
Genetic analysis of decreased praziquantel sensitivity in a laboratory strain of Schistosoma mansoni
Livia Pica-Mattoccia,Michael J. Doenhoff,Cristiana Valle,Annalisa Basso,Anna-Rita Troiani,Piero Liberti,Alfredo Festucci,Alessandra Guidi,Donato Cioli +8 more
TL;DR: It is concluded that hybrid schistosomes of the F(1) generation have a drug sensitivity intermediate between those of the two parental strains and are thus suggestive of a pattern of partial dominance for the trait under study.
Journal ArticleDOI
Schistosoma mansoni: lack of correlation between praziquantel-induced intra-worm calcium influx and parasite death.
Livia Pica-Mattoccia,Tiziana Orsini,Annalisa Basso,Alfredo Festucci,Piero Liberti,Alessandra Guidi,Ana-Luiza Marcatto-Maggi,Sonia Nobre-Santana,Anna-Rita Troiani,Donato Cioli,Cristiana Valle +10 more
TL;DR: It is suggested that calcium accumulation by itself, at least as measured in whole parasites maintained in vitro, may not represent an exhaustive explanation for the schistosomicidal effects of PZQ.
Journal ArticleDOI
Sequence and level of endogenous expression of calcium channel beta subunits in Schistosoma mansoni displaying different susceptibilities to praziquantel.
Cristiana Valle,Anna Rita Troiani,Alfredo Festucci,Livia Pica-Mattoccia,Piero Liberti,Adrian J. Wolstenholme,Katherine Francklow,Michael J. Doenhoff,Donato Cioli +8 more
TL;DR: It is suggested that cells expressing the structurally unusual schistosome beta subunit SmCavbeta1 in their voltage-operated calcium channels, exhibit an increased current amplitude in the presence of praziquantel (PZQ), which suggests that the beta sub unit is involved in PZQ activity and is consistent with the known pharmacological effects of the drug.
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Cytochalasin D abolishes the schistosomicidal activity of praziquantel.
Livia Pica-Mattoccia,Cristiana Valle,Annalisa Basso,Anna Rita Troiani,Fabio Vigorosi,Piero Liberti,Alfredo Festucci,Donato Cioli +7 more
TL;DR: Results are consistent with the hypothesis that schistosome calcium channels are involved in the mechanism of action of praziquantel.
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Stage-specific expression of a Schistosoma mansoni polypeptide similar to the vertebrate regulatory protein stathmin.
Cristiana Valle,Alfredo Festucci,Anna Calogero,Paola Macrı̀,Barbara Mecozzi,Piero Liberti,Donato Cioli +6 more
TL;DR: In vitro experiments demonstrated that SmSLP inhibits tubulin assembly and causes the depolymerization of preassembled microtubules, thus probably fulfilling regulatory roles in critical steps of schistosome development.