C
Cristiano G. Moreira
Researcher at Sao Paulo State University
Publications - 34
Citations - 2045
Cristiano G. Moreira is an academic researcher from Sao Paulo State University. The author has contributed to research in topics: Virulence & Escherichia coli. The author has an hindex of 16, co-authored 31 publications receiving 1676 citations. Previous affiliations of Cristiano G. Moreira include University of São Paulo & Instituto Butantan.
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Journal ArticleDOI
Targeting QseC Signaling and Virulence for Antibiotic Development
David A. Rasko,Cristiano G. Moreira,De Run Li,Nicola C. Reading,Jennifer M. Ritchie,Matthew K. Waldor,Noelle S. Williams,Ronald Taussig,Shuguang Wei,Michael G. Roth,David Hughes,Jason F. Huntley,Maggy Fina,John R. Falck,Vanessa Sperandio +14 more
TL;DR: Using a high-throughput screen, a small molecule is identified that inhibits the binding of signals to QseC, preventing its autophosphorylation and consequently inhibitingQseC-mediated activation of virulence gene expression, markedly inhibits the virulence of several pathogens in vitro and in vivo in animals.
Journal ArticleDOI
Fucose sensing regulates bacterial intestinal colonization.
Alline R. Pacheco,Meredith M. Curtis,Jennifer M. Ritchie,Diana Munera,Matthew K. Waldor,Cristiano G. Moreira,Vanessa Sperandio +6 more
TL;DR: It is suggested that EHEC uses fucose, a host-derived signal made available by the microbiota, to modulate EH EC pathogenicity and metabolism.
Journal ArticleDOI
QseC mediates Salmonella enterica serovar typhimurium virulence in vitro and in vivo.
TL;DR: QseC acts globally, regulating expression of genes within SPI-1 and SPI-2 in vitro and in vivo (during infection of mice), and dopamine β-hydroxylase knockout mice that do not produce Epi or NE showed different susceptibility to Salmonella serovar Typhimurium infection than wild-type mice.
Journal ArticleDOI
Virulence Meets Metabolism: Cra and KdpE Gene Regulation in Enterohemorrhagic Escherichia coli
TL;DR: This work shows how EHEC coopts established mechanisms for sensing the metabolites and stress cues in the environment, to induce virulence factors in a temporal and energy-efficient manner, culminating in disease.
Journal ArticleDOI
QseC Inhibitors as an Antivirulence Approach for Gram-Negative Pathogens
Meredith M. Curtis,Regan M. Russell,Cristiano G. Moreira,Adeniyi Michael Adebesin,Chang-Guang Wang,Noelle S. Williams,Ronald Taussig,Donald R. Stewart,Philippe E. Zimmern,Biao Lu,Ravi Naga Prasad,Chen Zhu,David A. Rasko,Jason F. Huntley,John R. Falck,Vanessa Sperandio +15 more
TL;DR: A broad-spectrum antivirulence approach targeting a conserved histidine kinase, QseC, in several Gram-negative pathogens that promotes their virulence expression is devised.