M
Michael G. Roth
Researcher at University of Texas Southwestern Medical Center
Publications - 159
Citations - 13203
Michael G. Roth is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Medicine & Internalization. The author has an hindex of 55, co-authored 120 publications receiving 12537 citations. Previous affiliations of Michael G. Roth include University of California, San Francisco & University of Alabama at Birmingham.
Papers
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Journal ArticleDOI
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
Baozhi Chen,Michael E. Dodge,Wei Tang,Jianming Lu,Zhiqiang Ma,Chih Wei Fan,Shuguang Wei,Wayne Hao,Jessica A. Kilgore,Noelle S. Williams,Michael G. Roth,James F. Amatruda,Chuo Chen,Lawrence G. Lum +13 more
TL;DR: Two novel classes of small molecules are discovered that disrupt Wnt pathway responses and contribute to Wnt-independent signal transduction pathways and thus could be broadly exploited for chemical genetics and therapeutic goals.
Journal ArticleDOI
Interaction of influenza virus haemagglutinin with sphingolipid–cholesterol membrane domains via its transmembrane domain
TL;DR: It is demonstrated that raft association is an intrinsic property encoded in the protein, and the data suggest that the binding to specific membrane domains can be encoded in transmembrane proteins and that this information will be used for polarized sorting and signal transduction processes.
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Role of lipid modifications in targeting proteins to detergent-resistant membrane rafts. Many raft proteins are acylated, while few are prenylated.
TL;DR: It is shown that at least half of the proteins in Madin-Darby canine kidney cell DRMs (other than cytoskeletal contaminants) could be labeled with [3H]palmitate, and partitioning of covalently linked saturated acyl chains into liquid-ordered phase domains is likely to be an important mechanism for targeting proteins to DRMs.
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Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi
Ying-Jie Wang,Jing Wang,Hui Qiao Sun,Manuel Martinez,Yu Xiao Sun,Eric Macia,Tomas Kirchhausen,Joseph P. Albanesi,Michael G. Roth,Helen L. Yin +9 more
TL;DR: It is proposed that PI4KIIalpha establishes the Golgi's unique lipid-defined organelle identity by generating PI(4)P-rich domains that specify the docking of the AP-1 coat machinery.
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Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
Andrew L. Rozelle,Laura M. Machesky,Masaya Yamamoto,Mariëtte H.E. Driessens,Robert H. Insall,Michael G. Roth,Katherine Luby-Phelps,Gerard Marriott,Alan Hall,Helen L. Yin +9 more
TL;DR: Overexpression of type I phosphatidylinositol phosphate 5-kinase (PIP5KI), which synthesizes PIP(2), promoted actin polymerization from membrane-bound vesicles to form motile actin comets, establishing that rafts promote comet formation.