C
Cristina Buges
Researcher at Catalan Institution for Research and Advanced Studies
Publications - 15
Citations - 561
Cristina Buges is an academic researcher from Catalan Institution for Research and Advanced Studies. The author has contributed to research in topics: Erlotinib & Cancer. The author has an hindex of 4, co-authored 12 publications receiving 412 citations.
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Journal ArticleDOI
Tumor-Related Molecular Mechanisms of Oxaliplatin Resistance
Eva Martinez-Balibrea,Anna Martínez-Cardús,Alba Ginés,Vicenç Ruiz de Porras,Catia Moutinho,Laura Layos,Jose Luis Manzano,Cristina Buges,Sara Bystrup,Manel Esteller,Manel Esteller,Albert Abad +11 more
TL;DR: This review will be focused on recent discoveries about oxaliplatin tumor-related resistance mechanisms, including alterations in transport, detoxification, DNA damage response and repair, cell death (apoptotic and nonapoptosis), and epigenetic mechanisms.
Journal ArticleDOI
Resistant mechanisms to BRAF inhibitors in melanoma
Jose Luis Manzano,Laura Layos,Cristina Buges,Maria de los Llanos Gil,Laia Vilà,Eva Martinez-Balibrea,Anna Martínez-Cardús +6 more
TL;DR: Mechanisms of resistance to targeted therapy and strategies to overcome them are commented on.
Journal ArticleDOI
Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway
Vicenç Ruiz de Porras,Sara Bystrup,Anna Martínez-Cardús,Raquel Pluvinet,Lauro Sumoy,Lynne M. Howells,Mark I. James,Chinenye Iwuji,Jose Luis Manzano,Laura Layos,Cristina Buges,Albert Abad,Eva Martinez-Balibrea +12 more
TL;DR: It is suggested that combination of OXA + Curcumin could be an effective treatment, for which CXCL1 could be used as a predictive marker, in CRC patients.
Journal ArticleDOI
Tumor Expression of Cyclin-Dependent Kinase 5 (Cdk5) Is a Prognostic Biomarker and Predicts Outcome of Oxaliplatin-Treated Metastatic Colorectal Cancer Patients.
Vicenç Ruiz de Porras,Sara Bystrup,Sara Cabrero De Las Heras,Eva Musulen,Luis Palomero,Maria Henar Alonso,Rocio Nieto,Diego Arango,Victor Moreno,Cristina Queralt,Jose Luis Manzano,Laura Layos,Cristina Buges,Eva Martinez-Balibrea +13 more
TL;DR: It is confirmed that Cdk5 is involved in CRC and disease progression and that it could serve as a prognostic and predictive biomarker in this disease.
Journal ArticleDOI
Rectal neuroendocrine carcinoma: case report of a rare entity and perspective review of promising agents.
Gabriela Antelo,Cinta Hierro,Juan Pablo Fernández,Eduardo Baena,Cristina Buges,Laura Layos,Jose Luis Manzano,Monica Caro,Ricard Mesia +8 more
TL;DR: The current management of NECs is discussed, an overview of the most relevant molecular findings are provided and the potential value that prescreening panels can offer is illustrated, searching for actionable targets to guide therapy with promising agents that could fill a void in this disease.