C
Catia Moutinho
Researcher at University of Porto
Publications - 61
Citations - 5366
Catia Moutinho is an academic researcher from University of Porto. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 34, co-authored 58 publications receiving 4285 citations. Previous affiliations of Catia Moutinho include Carlos III Health Institute & Institute of Molecular Pathology and Immunology of the University of Porto.
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Journal ArticleDOI
A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function
Sonia A. Melo,Santiago Ropero,Catia Moutinho,Lauri A. Aaltonen,Hiroyuki Yamamoto,George A. Calin,Simona Rossi,Agustín F. Fernández,Fátima Carneiro,Carla Oliveira,Bibiana Ferreira,Chang Gong Liu,Alberto Villanueva,Gabriel Capella,Simó Schwartz,Ramin Shiekhattar,Manel Esteller +16 more
TL;DR: This work has identified truncating mutations in TARBP2 (TAR RNA-binding protein 2), encoding an integral component of a DICER1-containing complex, in sporadic and hereditary carcinomas with microsatellite instability, and provides an explanation for the observed defects in the expression of mature miRNAs.
Journal ArticleDOI
A Genetic Defect in Exportin-5 Traps Precursor MicroRNAs in the Nucleus of Cancer Cells
Sonia A. Melo,Catia Moutinho,Santiago Ropero,George A. Calin,Simona Rossi,Riccardo Spizzo,Agustín F. Fernández,Veronica Davalos,Alberto Villanueva,Guillermo Montoya,Hiroyuki Yamamoto,Simó Schwartz,Manel Esteller +12 more
TL;DR: The restoration of XPO5 functions reverses the impaired export of pre-miRNAs and has tumor-suppressor features.
Journal ArticleDOI
Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis
Sebastian Moran,Anna Martínez-Cardús,Sergi Sayols,Eva Musulen,C. Balana,Anna Estival-Gonzalez,Catia Moutinho,Holger Heyn,Angel Diaz-Lagares,Manuel Castro de Moura,Giulia Maria Stella,Paolo M. Comoglio,Maria Ruiz-Miró,Xavier Matias-Guiu,Roberto Pazo-Cid,Antonio Antón,Rafael López-López,Gemma Soler,Federico Longo,Isabel Guerra,Sara Fernandez,Yassen Assenov,Christoph Plass,Rafael Morales,Joan Carles,David D.L. Bowtell,David D.L. Bowtell,Linda Mileshkin,Linda Mileshkin,Daniela Sia,Richard W. Tothill,Richard W. Tothill,Josep Tabernero,Josep M. Llovet,Manel Esteller,Manel Esteller +35 more
TL;DR: The development of a DNA methylation based assay can significantly improve diagnoses of cancer of unknown primary and guide more precise therapies associated with better outcomes.
Journal ArticleDOI
Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
Veronica Davalos,Catia Moutinho,A. Villanueva,Raquel Boque,Paula Silva,Fátima Carneiro,Manel Esteller,Manel Esteller +7 more
TL;DR: It is discovered that the miR-200 epigenetic silencing is not an static and fixed process but it can be shifted to hypermethylated or unmethylated 5′-CpG island status corresponding to the EMT and MET phenotypes, respectively.
Journal ArticleDOI
Benchmarking Single-Cell RNA Sequencing Protocols for Cell Atlas Projects
Elisabetta Mereu,Atefeh Lafzi,Catia Moutinho,Christoph Ziegenhain,Davis J. McCarthy,Davis J. McCarthy,Adrián Álvarez-Varela,Eduard Batlle,Sagar,Dominic Grün,Julia K. Lau,Stéphane C. Boutet,Chad Sanada,Aik Ooi,Robert C. Jones,Kelly Kaihara,Chris Brampton,Yasha Talaga,Yohei Sasagawa,Kaori Tanaka,Tetsutaro Hayashi,Caroline Braeuning,Cornelius Fischer,Sascha Sauer,Timo Trefzer,Christian Conrad,Xian Adiconis,Lan T. Nguyen,Aviv Regev,Aviv Regev,Aviv Regev,Joshua Z. Levin,Swati Parekh,Aleksandar Janjic,Lucas E. Wange,Johannes W. Bagnoli,Wolfgang Enard,Marta Gut,Rickard Sandberg,Itoshi Nikaido,Ivo Gut,Oliver Stegle,Oliver Stegle,Holger Heyn +43 more
TL;DR: In this paper, a multicenter study comparing 13 commonly used scRNA-seq and single-nucleus RNA-seq protocols applied to a heterogeneous reference sample resource was conducted.