Cristina Romero-López

TL;DR: It is shown that UNC5A is cumulatively downregulated by the UPR at the transcriptional level in vitro and at the translational level both in veteran and in vivo, suggesting linked translational regulatory mechanisms, at least during the initial stages of the U PR.

TL;DR: This review summarizes major achievements in the development of emerging methodologies for the analysis of RNA folding and their application to the study of the HCV genome structure and the design of novel antiviral compounds based in nucleic acids able to interfere with the folding of functional RNA domains.

TL;DR: This work describes two well documented examples of RNA aptamers with antiviral activity against highly conserved structural domains of the HIV-1 and HCV RNA genome, respectively, performed in the laboratory.

TL;DR: The 3'X domain of hepatitis C virus has been reported to control viral replication and translation by modulating the exposure of a nucleotide segment involved in a distal base-pairing interaction with an upstream 5BSL3.2 domain, but the switch function attributed to the 3' X domain does not occur as a result of a transition between two- and three-stem conformations, but likely through the sequestration of the 5BS ligation sequence.

TL;DR: This chapter summarizes the general principles in the design of hairpin ribozymes for targeting purposes, and provides a brief overview of the well-characterized modifications of the ribozyme sequences and structural domains that are necessary for optimal activity.