C
CY Tsou
Researcher at Public Health England
Publications - 7
Citations - 167
CY Tsou is an academic researcher from Public Health England. The author has contributed to research in topics: Tuberculin & Latent tuberculosis. The author has an hindex of 4, co-authored 7 publications receiving 110 citations.
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Journal ArticleDOI
Prognostic value of interferon-γ release assays and tuberculin skin test in predicting the development of active tuberculosis (UK PREDICT TB): a prospective cohort study
Ibrahim Abubakar,Francis Drobniewski,Jo Southern,Alice J Sitch,Charlotte Jackson,M Lipman,Jonathan J Deeks,Chris Griffiths,Graham H. Bothamley,William Lynn,H Burgess,B Mann,Imran A,Saranya Sridhar,CY Tsou,Nikolayevskyy,Melanie Rees-Roberts,Hilary S. Whitworth,Onn Min Kon,Pranabashis Haldar,Heinke Kunst,Sarah R Anderson,Andrew Hayward,John M Watson,H Milburn,Ajit Lalvani,Predict Study Team +26 more
TL;DR: IGRA-based or BCG-stratified TST strategies appear most suited to screening for potential disease progression among high-risk groups, and positive results for these tests were significantly better predictors of progression than TST-10 and T ST-5.
Journal ArticleDOI
Quantitative IFN-γ Release Assay and Tuberculin Skin Test Results to Predict Incident Tuberculosis. A Prospective Cohort Study
Rishi K Gupta,Marc Lipman,Charlotte Jackson,Alice J Sitch,Jo Southern,Francis Drobniewski,Jonathan J Deeks,Jonathan J Deeks,CY Tsou,Christopher E.M. Griffiths,Jennifer Davidson,Colin Campbell,Oliver Stirrup,Mahdad Noursadeghi,Heinke Kunst,Pranab Haldar,Ajit Lalvani,Ibrahim Abubakar +17 more
TL;DR: Implementing higher diagnostic thresholds for QuantiFERON Gold-in-Tube, T-SPOT.TB and the tuberculin skin test modestly increases PPV for incident TB, but markedly reduces sensitivity.
Journal ArticleDOI
Diabetes mellitus and latent tuberculosis infection: baseline analysis of a large UK cohort
Charlotte Jackson,Jo Southern,Ajit Lalvani,Francis Drobniewski,Chris Griffiths,Marc Lipman,Graham H. Bothamley,Jonathan J Deeks,Jonathan J Deeks,Ambreen Imran,Onn Min Kon,Sithembinkosi Mpofu,Vladyslav Nikolayevskyy,Melanie Rees-Roberts,Alice J Sitch,Saranya Sridhar,CY Tsou,Hilary S. Whitworth,Ibrahim Abubakar +18 more
TL;DR: A cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI) found that DM was associated with a 15% higher prevalence of LTBI.
Journal ArticleDOI
Discordance in latent tuberculosis (TB) test results in patients with end-stage renal disease
Jo Southern,Saranya Sridhar,CY Tsou,Susan Hopkins,Sophie Collier,Vladyslav Nikolayevskyy,S Lozewicz,Ajit Lalvani,Ibrahim Abubakar,Marc Lipman +9 more
TL;DR: There is a low risk of progression to active TB in low-incidence countries even in high-risk groups, and the degree of the test result discordance emphasises the complexities of managing TB in such settings as it is unclear which of these tests, if any, provides the best diagnostic accuracy.
Proceedings ArticleDOI
S31 Prognostic value of interferon gamma release assays and tuberculin skin test in predicting the development of active tuberculosis: the uk predict tb cohort study
Ibrahim Abubakar,Francis Drobniewski,Jo Southern,Alice J Sitch,Charlotte Jackson,M Lipman,JJ Deeks,Chris Griffiths,Graham H. Bothamley,W Lynn,H Burgess,B Mann,A Imran,Saranya Sridhar,CY Tsou,Vladyslav Nikolayevskyy,Melanie Rees-Roberts,Hilary S. Whitworth,O Min Kon,Pranabashis Haldar,Heinke Kunst,Sarah R Anderson,Andrew Hayward,John M Watson,H Milburn,Ajit Lalvani +25 more
TL;DR: IGRA-based or TST15 strategies are most suited for population screening in low-risk populations and TST5 predicted more at high risk than TST10, TSpot.TB and QFT.GIT, and positive test results for these tests were significantly more predictive of progression.