C
Cynthia D. Thompson
Researcher at National Institutes of Health
Publications - 37
Citations - 4505
Cynthia D. Thompson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Capsid & Cytotoxic T cell. The author has an hindex of 24, co-authored 35 publications receiving 4121 citations. Previous affiliations of Cynthia D. Thompson include Center for Biologics Evaluation and Research & Food and Drug Administration.
Papers
More filters
Journal ArticleDOI
Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan
Jeffrey N. Roberts,Christopher B. Buck,Cynthia D. Thompson,Rhonda C. Kines,Marcelino Bernardo,Peter L. Choyke,Douglas R. Lowy,John T. Schiller +7 more
TL;DR: Development of a mouse model of cervicovaginal infection with HPV16 that recapitulates the establishment phase of papillomavirus infection is reported, and carrageenan, a polysaccharide present in some vaginal lubricants, prevented infection even in the presence of N-9, suggesting that carrageinan might serve as an effective topical HPV microbicide.
Journal ArticleDOI
Carrageenan Is a Potent Inhibitor of Papillomavirus Infection
Christopher B. Buck,Cynthia D. Thompson,Jeffrey N. Roberts,Martin Müller,Douglas R. Lowy,John T. Schiller +5 more
TL;DR: Comparison of a variety of compounds revealed that carrageenan, a type of sulfated polysaccharide extracted from red algae, is an extremely potent infection inhibitor for a broad range of sexually transmitted HPVs.
Journal ArticleDOI
Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18
Diana V. Pastrana,Christopher B. Buck,Yuk Ying S. Pang,Cynthia D. Thompson,Philip E. Castle,Peter C. FitzGerald,Susanne K. Kjaer,Douglas R. Lowy,John T. Schiller +8 more
TL;DR: The SEAP pseudovirus-based neutralization assay should be a practical method for quantifying potentially protective antibody responses in HPV natural history and prophylactic vaccine studies.
Journal ArticleDOI
Arrangement of L2 within the Papillomavirus Capsid
Christopher B. Buck,Naiqian Cheng,Cynthia D. Thompson,Douglas R. Lowy,Alasdair C. Steven,John T. Schiller,Benes L. Trus +6 more
TL;DR: Methods for serial propagation of infectious HPV16 capsids (pseudoviruses) in cultured human cell lines are developed and structural information should facilitate investigation of L2 function during the assembly and entry phases of the papillomavirus life cycle.
Journal ArticleDOI
Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies.
Kanneboyina Nagaraju,Nina Raben,Lisa Loeffler,Tomasina Parker,Paul J. Rochon,Eunice Lee,Carol L. Danning,Ryuichi Wada,Cynthia D. Thompson,Gul Bahtiyar,Joe Craft,Rob Hooft van Huijsduijnen,Paul H. Plotz +12 more
TL;DR: It is suggested that an autoimmune disease may unfold in a highly specific pattern as the consequence of an apparently nonspecific event-the sustained up-regulation of MHC class I in a tissue-and that the specificity of the autoantibodies derives not from the specificityOf the stimulus, but from the context, location, and probably the duration of the stimulus.