Showing papers by "Cynthia J. Meininger published in 1998"
TL;DR: It is concluded that VEGF upregulates ecNOS enzyme and elicits a biphasic stimulation of endothelial NO production, and regulates endothelial production of NO.
Abstract: Vascular endothelial growth factor (VEGF) is an endothelium-specific secreted protein that potently stimulates vasodilation, microvascular hyperpermeability, and angiogenesis. Nitric oxide (NO) is ...
659 citations
TL;DR: The results suggest that PAF induces vasoconstriction and hyperpermeability in coronary arterioles via an endothelium-dependent and neutrophil-mediated mechanism, and PAF is able to stimulate neutrophIL adhesion in coronary arteries under a condition of low flow rate.
Abstract: Platelet-activating factor (PAF) has been implicated in the pathogenesis of ischemic heart disease, reperfusion injury, and inflammatory reactions. Although neutrophils have been shown to primarily...
23 citations
01 Jan 1998
TL;DR: Through the interplay of tissue oxygen tension, adenosine, nitric oxide and vascular endothelial growth factor, a complex physiological control system ensures the matching of vascularity and metabolic needs in a variety of organs and circumstances.
Abstract: Angiogenesis, the formation of new microvessels from a pre-existing vascular bed, is stimulated by tissue hypoxia. Adenosine, a key extracellular signal elicited by hypoxia, plays several roles in initiation and/or modulation of angiogenesis. Adenosine governs the angiogenesis process through its actions on endothelial cell proliferation and migration. In addition, adenosine amplifies the mitogenic signal elicited by other angiogenic mediators such as nitric oxide and vascular endothelial growth factor. Through the interplay of tissue oxygen tension, adenosine, nitric oxide and vascular endothelial growth factor, a complex physiological control system ensures the matching of vascularity and metabolic needs in a variety of organs and circumstances.
2 citations