C
Cynthia L. Forsman
Researcher at Mayo Clinic
Publications - 8
Citations - 397
Cynthia L. Forsman is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Cell therapy & Chimeric antigen receptor. The author has an hindex of 3, co-authored 7 publications receiving 231 citations.
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Journal ArticleDOI
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
Rosalie M. Sterner,Reona Sakemura,Michelle J. Cox,Nan Yang,Roman H. Khadka,Cynthia L. Forsman,Michael J. Hansen,Fang Jin,Katayoun Ayasoufi,Mehrdad Hefazi,Kendall J. Schick,Denise K. Walters,Omar H. Ahmed,Dale Chappell,Tarek Sahmoud,Cameron Durrant,Wendy K. Nevala,Mrinal M. Patnaik,Larry R. Pease,Karen E. Hedin,Neil E. Kay,Aaron J. Johnson,Saad S. Kenderian +22 more
TL;DR: It is shown that GM-CSF neutralization with lenzilumab does not inhibit CART19 cell function in vitro or in vivo, and a novel approach to abrogate NI and CRS through GM- CSF neutralized, which may potentially enhance CAR-T cell function.
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Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia.
Michelle J. Cox,Michelle J. Cox,Fabrice Lucien,Reona Sakemura,Justin C. Boysen,Yohan Kim,Paulina Horvei,Claudia Manriquez Roman,Michael J. Hansen,Erin E. Tapper,Elizabeth L. Siegler,Cynthia L. Forsman,Sydney B. Crotts,Kendall J. Schick,Mehrdad Hefazi,Michael W. Ruff,Ismail Can,Mohamad M. Adada,Evandro D. Bezerra,Lionel A. Kankeu Fonkoua,Wendy K. Nevala,Esteban Braggio,Wei Ding,Sameer A. Parikh,Neil E. Kay,Saad S. Kenderian +25 more
TL;DR: In this article, the authors used chronic lymphocytic leukemia (CLL) as a model to investigate the interactions between the tumor microenvironment and CART cells and found that CLL-derived EVs were able to induce a state of CART cell dysfunction characterized by phenotypical, functional and transcriptional changes of exhaustion.
Journal ArticleDOI
GM-CSF Blockade during Chimeric Antigen Receptor T Cell Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance Their Effector Functions
Rosalie M. Sterner,Reona Sakemura,Nan Yang,Michelle J. Cox,Roman H. Khadka,Cynthia L. Forsman,Michael J. Hansen,Fang Jin,Katayoun Ayasoufi,Mehrdad Hefazi,Baustin M. Welch,Kendall J. Schick,Denise K. Walters,German Martinez,Omar H. Ahmed,Tarek Sahmoud,Cameron Durrant,Wendy K. Nevala,Mrinal M. Patnaik,Stephen J. Russell,Larry R. Pease,Neil E. Kay,Karen E. Hedin,Aaron J. Johnson,Saad S. Kenderian +24 more
TL;DR: The role of GM-CSF neutralization in preventing CRS and NT after CART cell therapy via monocyte control is investigated and it is found that malignancy associated macrophages reduce CART proliferation.
Journal ArticleDOI
GM-CSF Blockade during Chimeric Antigen Receptor T-Cell (CART) Therapy Reduces Cytokine Release Syndrome and Neurotoxicity and May Enhance CART Effector Functions
Rosalie M. Sterner,Reona Sakemura,Nan Yang,Michelle J. Cox,Roman H. Khadka,Cynthia L. Forsman,Michael J. Hansen,Fang Jin,Katayoun Ayasoufi,Mehrdad Hefazi,Baustin M. Welch,Kendall J. Schick,Denise K. Walters,German Martinez,Omar H. Ahmed,Tarek Sahmoud,Cameron Durrant,Wendy K. Nevala,Mrinal M. Patnaik,Stephen J. Russell,Larry R. Pease,Neil E. Kay,Karen E. Hedin,Aaron J. Johnson,Saad S. Kenderian +24 more
TL;DR: The role of GM-CSF neutralization in preventing CRS and NT after CART cell therapy via monocyte control is investigated and a phase II clinical trial using lenzilumab as a modality to prevent CART related toxicities in patients with diffuse large B cell lymphoma is designed.
Journal ArticleDOI
Baseline immune dysregulation in autologous stem cell transplant recipients is associated with a 'graft versus host'-like syndrome and poor outcomes.
Theodora Anagnostou,Reona Sakemura,Cynthia L. Forsman,Mrinal S. Patnaik,Jonas Paludo,Dennis A. Gastineau,Francis K. Buadi,Luis F. Porrata,Shaji Kumar,Morie A. Gertz,Matha Q. Lacy,Angela Dispenzieri,Wilson I. Gonsalves,Julia S. Lehman,William J. Hogan,Shahrukh K. Hashmi,Hassan B. Alkhateeb,Mithun Vinod Shah,Mark R. Litzow,Saad S. Kenderian +19 more
TL;DR: A retrospective analysis of patients who received ASCT at Mayo Clinic between January 2006 and December 2016 to analyze outcomes, clinical and histopathological correlatives for the development of autologous GVHD in ASCT recipients and determine baseline Tand NKcell functions in patients who developed GV HD after ASCT compared with matched controls.