M
Michael J. Hansen
Researcher at Mayo Clinic
Publications - 55
Citations - 1106
Michael J. Hansen is an academic researcher from Mayo Clinic. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 13, co-authored 55 publications receiving 787 citations.
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Journal ArticleDOI
GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
Rosalie M. Sterner,Reona Sakemura,Michelle J. Cox,Nan Yang,Roman H. Khadka,Cynthia L. Forsman,Michael J. Hansen,Fang Jin,Katayoun Ayasoufi,Mehrdad Hefazi,Kendall J. Schick,Denise K. Walters,Omar H. Ahmed,Dale Chappell,Tarek Sahmoud,Cameron Durrant,Wendy K. Nevala,Mrinal M. Patnaik,Larry R. Pease,Karen E. Hedin,Neil E. Kay,Aaron J. Johnson,Saad S. Kenderian +22 more
TL;DR: It is shown that GM-CSF neutralization with lenzilumab does not inhibit CART19 cell function in vitro or in vivo, and a novel approach to abrogate NI and CRS through GM- CSF neutralized, which may potentially enhance CAR-T cell function.
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Prevalent Class I-Restricted T-Cell Response to the Theiler’s Virus Epitope Db:VP2121–130 in the Absence of Endogenous CD4 Help, Tumor Necrosis Factor Alpha, Gamma Interferon, Perforin, or Costimulation through CD28
Aaron J. Johnson,M. Kariuki Njenga,Michael J. Hansen,Scott T. Kuhns,Lieping Chen,Moses Rodriguez,Larry R. Pease +6 more
TL;DR: Results demonstrate that VP2121–130 presented in the context of Db is an immunodominant epitope in TMEV infection and that the frequency of the VP2 121–130-specific CTLs appears to be independent of several key inflammatory mediators and genetic background but is regulated in part by the expression of CD4.
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Systemic Delivery of Human Growth Hormone or Human Factor IX in Dogs by Reintroduced Genetically Modified Autologous Bone Marrow Stromal Cells
David R. Hurwitz,Michael Kirchgesser,Wilma Merrill,Theofanis Galanopoulos,Claire A. Mcgrath,Shahin Emami,Michael J. Hansen,Van Cherington,Joseph M. Appel,Christine B. Bizinkauskas,Hans Herrmann Brackmann,Peter H Levine,Joel S. Greenberger +12 more
TL;DR: The results demonstrate that the ex vivo bone marrow stromal cell system is a potentially powerful method by which to deliver secreted transgene product to the systemic circulation of large animals.
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Donor-specific hypo-responsiveness occurs in simultaneous liver-kidney transplant recipients after the first year
Timucin Taner,Michael P. Gustafson,Michael J. Hansen,Walter D. Park,Svetlana Bornschlegl,Allan B. Dietz,Mark D. Stegall +6 more
TL;DR: The phenotypic and functional characteristics of the circulating blood cells of the simultaneous liver-kidney transplant recipients resembled those of solitary liver transplant recipients, and appear to be associated with donor-specific hypo-alloresponsiveness.
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Retroviral vector-modified bone marrow stromal cells secrete biologically active factor IX in vitro and transiently deliver therapeutic levels of human factor IX to the plasma of dogs after reinfusion.
Van Cherington,Gisela G. Chiang,Claire A. Mcgrath,Anita Gaffney,Theofanis Galanopoulos,Wilma Merrill,Christine B. Bizinkauskas,Michael J. Hansen,Joyce Sobolewski,Peter H Levine,Joel S. Greenberger,David R. Hurwitz +11 more
TL;DR: It is demonstrated that retroviral vector-modified BMSCs can deliver human therapeutic levels of hFIX to the circulation of dogs and that dog anti-hFIX antibodies may have masked potentially longer duration expression in vivo.