D. L. Loriaux

TL;DR: The pathophysiologic features of hypercortisolism in depression and Cushing's disease are distinct in each of the disorders and that the ovine corticotropin-releasing hormone stimulation test can be helpful in their differential diagnosis.

TL;DR: It is concluded that physical conditioning is associated with a reduction in pituitary-adrenal activation in response to a given workload and Alterations of the hypothalamic-pituitary and adrenal axis consistent with mild hypercortisolism and similar to findings in depression and anorexia nervosa were found only in highly trained runners.

TL;DR: Clinically, experience in administering ovine CRF shows that CRF can be helpful in resolving differential diagnostic dilemmas in patients with various disorders of the hypothalamic-pituitary-adrenal axis and in furthering an understanding of the pathophysiology of conditions such as Cushing's disease and depression.

TL;DR: Cortisol resistance is a rare familial syndrome owing to an abnormal glucocorticoid receptor with a decreased affinity for cortisol in patients with apparent end-organ resistance to cortisol.

TL;DR: The findings suggest that the permissive actions of physiologic glucocorticoid replacement are both necessary and sufficient for primates to tolerate surgical stress.