David Pickar

TL;DR: In the clinical study, patients with schizophrenia compared with healthy volunteers had significantly greater amphetamine-related reductions in [11C]raclopride specific binding, providing direct evidence for the hypothesis of elevated Amphetamine-induced synaptic dopamine concentrations in schizophrenia.

TL;DR: The pathophysiologic features of hypercortisolism in depression and Cushing's disease are distinct in each of the disorders and that the ovine corticotropin-releasing hormone stimulation test can be helpful in their differential diagnosis.

TL;DR: The effects of subanesthetic doses of ketamine on two forms of memory, free recall and recognition, as well as attention and behavior in 15 healthy volunteers are examined, suggesting that the NMDA receptor plays a direct role in two types of explicit memory.

TL;DR: Level of positive and negative symptoms ascertained when patients received optimal neuroleptic treatment during the index hospitalization significantly predicted outcome levels of symptoms and functioning and time spent hospitalized during the follow-up period, suggesting that treatment response is a critical predictor variable for the course of illness in schizophrenics.

TL;DR: Data suggest that the prefrontal cortex may be involved in mediating NMDA receptor-induced psychosis, and a change in one psychotic symptom, conceptual disorganization, was significantly related to prefrontal activation.