William T. Gallucci

TL;DR: The pathophysiologic features of hypercortisolism in depression and Cushing's disease are distinct in each of the disorders and that the ovine corticotropin-releasing hormone stimulation test can be helpful in their differential diagnosis.

TL;DR: It is concluded that physical conditioning is associated with a reduction in pituitary-adrenal activation in response to a given workload and Alterations of the hypothalamic-pituitary and adrenal axis consistent with mild hypercortisolism and similar to findings in depression and anorexia nervosa were found only in highly trained runners.

TL;DR: The findings suggest that serotonin stimulates CRH secretion by explanted rat hypothalami and that this effect appears to be mediated mainly through a 5HT2 receptor mechanism.

TL;DR: The results suggest that patients with panic disorder have an element of chronic hypercortisolemia, like depressed patients, but also a more acute perturbation in ACTH secretion, not previously seen in depressed patients.

TL;DR: It is concluded that hCRF causes brief plasma ACTH and cortisol secretory episodes in man, similar to the physiological plasma ACTh and cortisolsecretory episodes, in contrast to oCRF, which causes prolonged ACTHand cortisol secretion.