D Y Mason

TL;DR: Investigation of whether oncogenic tyrosine kinase activation also occurs in other categories of lymphoma covering those tumours with a range of different subtypes including those with morphological similarity to ALK-positive anaplastic large cell lymphoma (ALCL) concluded that activation of a tyrosin kinase is probably not a major oncogens event in lymphomas other than ALK -positive ALCL.

TL;DR: Cloning of the translocation breakpoint has shown the fusion of a previously unidentified protein tyrosine kinase, anaplastic lymphoma kinase (ALK), which is an established cytogenetic abnormality associated with 40% of cases of anaPLastic large-cell lymphoma (ALCL).

TL;DR: The pattern of reactivity of 4KB51 suggests that its target antigen may play a functional role, possibly involved in lymphocyte homing, and may be of value in defining B-cell subsets and in the differential diagnosis of hairy cell leukaemia and centrocytic lymphomas.

TL;DR: Renal biopsies taken from 42 patients at seven and 21 days after renal transplantation concluded that glomerular capillary thromboses are not frequent in patients on cyclosporin A alone, and microthrombi are found mainly in Patients on multiple drug therapy, particularly when steroids are included.

TL;DR: Findings show that lymphomas recognised immunocytochemically behave similarly to other lymphomas and confirm that immunohistological analysis of tumours of uncertain origin is of practical clinical relevance.