D
Dae Joong Kang
Researcher at Virginia Commonwealth University
Publications - 16
Citations - 4620
Dae Joong Kang is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Bile acid & Gut flora. The author has an hindex of 13, co-authored 16 publications receiving 3497 citations. Previous affiliations of Dae Joong Kang include VCU Medical Center.
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Journal ArticleDOI
Bile salt biotransformations by human intestinal bacteria.
TL;DR: The potential exists for altering the bile acid pool by targeting key enzymes in the 7α/β-dehydroxylation pathway through the development of pharmaceuticals or sequestering bile acids biologically in probiotic bacteria, which may result in their effective removal from the host after excretion.
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Bile Acids and the Gut Microbiome
TL;DR: The host and microbiome appear to regulate bile acid pool size, and members of the microbiome utilize bile acids and their conjugates resulting in agonism of FXR in intestine and liver resulting in a smaller, unconjugated hydrophobic bile Acid pool.
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Consequences of bile salt biotransformations by intestinal bacteria
TL;DR: Elucidating methods to control the gut microbiome and bile acid pool composition in humans may lead to a reduction in some of the major diseases of the liver, gall bladder and colon.
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Salivary microbiota reflects changes in gut microbiota in cirrhosis with hepatic encephalopathy
Jasmohan S. Bajaj,Naga S. Betrapally,Phillip B. Hylemon,Douglas M. Heuman,Kalyani Daita,Melanie B. White,Ariel Unser,Leroy R. Thacker,Arun J. Sanyal,Dae Joong Kang,Masoumeh Sikaroodi,Patrick M. Gillevet +11 more
TL;DR: Dysbiosis, represented by reduction in autochthonous bacteria, is present in both saliva and stool in patients with Cirrhosis, compared to controls, which could represent a global mucosal‐immune interface change in cirrhosis.
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Colonic inflammation and secondary bile acids in alcoholic cirrhosis.
Genta Kakiyama,Phillip B. Hylemon,Huiping Zhou,William M. Pandak,Douglas M. Heuman,Dae Joong Kang,Hajime Takei,Hiroshi Nittono,Jason M. Ridlon,Michael Fuchs,Emily C. Gurley,Yun Wang,Runping Liu,Arun J. Sanyal,Patrick M. Gillevet,Jasmohan S. Bajaj +15 more
TL;DR: Active alcohol use in cirrhosis is associated with a significant increase in the secondary BA formation compared with abstinent alcoholic cirrhotics and nonalcoholic cirr hotics, which may contribute to alcohol-induced gut barrier injury.