Journal•ISSN: 0267-1379
Current Opinion in Gastroenterology
Lippincott Williams & Wilkins
About: Current Opinion in Gastroenterology is an academic journal published by Lippincott Williams & Wilkins. The journal publishes majorly in the area(s): Medicine & Inflammatory bowel disease. It has an ISSN identifier of 0267-1379. Over the lifetime, 2197 publications have been published receiving 57444 citations.
Topics: Medicine, Inflammatory bowel disease, Disease, Internal medicine, Cancer
Papers published on a yearly basis
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TL;DR: There is a fast growing collection of data describing the structure and functional capacity of the microbiome in a variety of conditions available to the research community for consideration and further exploration.
Abstract: Purpose of reviewRecent technological advancements and expanded efforts have led to a tremendous growth in the collective knowledge of the human microbiome. This review will highlight some of the important recent findings in this area of research.Recent findingsStudies have described the structure a
1,122 citations
TL;DR: The host and microbiome appear to regulate bile acid pool size, and members of the microbiome utilize bile acids and their conjugates resulting in agonism of FXR in intestine and liver resulting in a smaller, unconjugated hydrophobic bile Acid pool.
Abstract: Purpose of the review
We examine the latest research on the emerging bile acid-gut microbiome axis and its role in health and disease. Our focus revolves around two key microbial pathways for degrading bile salts, and the impact of bile acid composition in the gut on the gut microbiome and host physiology.
896 citations
TL;DR: Large-scale alterations of the gut microbiota and its microbiome (gene content) are associated with obesity and are responsive to weight loss, and Restoration of the guts to a healthy state may ameliorate the conditions associated with Obesity and help maintain a healthy weight.
Abstract: Purpose of review Obesity was once rare, but the last few decades have seen a rapid expansion of the proportion of obese individuals worldwide. Recent work has shown obesity to be associated with a shift in the representation of the dominant phyla of bacteria in the gut, both in humans and animal models. This review summarizes the latest research into the association between microbial ecology and host adiposity, and the mechanisms by which microbes in the gut may mediate host metabolism in the context of obesity. Recent findings Studies of the effect of excess body fat on the abundances of different bacteria taxa in the gut generally show alterations in the gastrointestinal microbiota, and changes during weight loss. The gastrointestinal microbiota have been shown to impact insulin resistance, inflammation, and adiposity via interactions with epithelial and endocrine cells. Summary Large-scale alterations of the gut microbiota and its microbiome (gene content) are associated with obesity and are responsive to weight loss. Gut microbes can impact host metabolism via signaling pathways in the gut, with effects on inflammation, insulin resistance, and deposition of energy in fat stores. Restoration of the gut microbiota to a healthy state may ameliorate the conditions associated with obesity and help maintain a healthy weight.
723 citations
TL;DR: Thailand is still the country with the highest incidence of cholangiocarcinoma in the world, and eradication of the fluke and identification of high-risk populations are urgently needed.
Abstract: Purpose of reviewTo present the background of liver fluke-associated cholangiocarcinoma in Thailand focusing on recent epidemiological data and pathogenesis of this bile duct cancer.Recent findingsMore systematic tumor registration in Thailand nowadays uncovers new high-incidence areas that are conf
429 citations
TL;DR: Large-scale shifts in gut commensal populations, rather than occurrence of particular microorganisms, are associated with several gastroenterological conditions; redress of these imbalances may ameliorate the conditions.
Abstract: Purpose of reviewAdvances in DNA sequence-based technologies now permit genetic analysis of complex microbial populations without the need for prior cultivation. This review summarizes the molecular methods of culture-independent microbiology (‘metagenomics’) and their recent application to studies
400 citations