D
Dag Jenssen
Researcher at Stockholm University
Publications - 70
Citations - 2755
Dag Jenssen is an academic researcher from Stockholm University. The author has contributed to research in topics: Homologous recombination & Chinese hamster. The author has an hindex of 27, co-authored 70 publications receiving 2681 citations. Previous affiliations of Dag Jenssen include Kerman Medical University.
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Journal ArticleDOI
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
Cecilia Lundin,Matthew North,Klaus Erixon,Kevin Walters,Dag Jenssen,Alastair S. H. Goldman,Thomas Helleday +6 more
TL;DR: It is shown that DNA fragmentation following MMS treatment, and detected by PFGE is not the consequence of production of cellular DSBs, and that the repair of MMS-induced heat-labile damage requires the base excision repair protein XRCC1, and is independent of HR in both S.cerevisiae and mammalian cells.
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Different roles for nonhomologous end joining and homologous recombination following replication arrest in mammalian cells.
Cecilia Lundin,Klaus Erixon,Catherine Arnaudeau,Niklas Schultz,Dag Jenssen,Mark Meuth,Thomas Helleday,Thomas Helleday +7 more
TL;DR: It is shown that the arrest of replication with hydroxyurea generates DNA fragmentation as a consequence of the formation of DSBs at newly replicated DNA.
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The micronucleus test as part of a short-term mutagenicity test program for the prediction of carcinogenicity evaluated by 143 agents tested.
Dag Jenssen,Claes Ramel +1 more
TL;DR: The finding that the combination of Ames's test and the micronucleus test did increase the screening procedure for the prediction of carcinogenic effects is emphasized by the finding that it is an in vivo method, which may pick up effects at the chromosomal level not covered by bacterial assays.
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Brominated flame retardants induce intragenic recombination in mammalian cells.
TL;DR: The findings indicate that the modern additives to plastic, i.e., HBCD and PBDEs, as well as the plastic monomer BCPS may have the same effect to human health as DDT and PCBs, in terms of inducing genetic recombination, which is known to provoke a number of diseases, including cancer.
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Dose response at low doses of X-irradiation and MMS on the induction of micronuclei in mouse erythroblasts.
Dag Jenssen,Claes Ramel +1 more
TL;DR: The test of induced micronuclei in erythrocytes of mammalian bone marrow constitutes a suitable method for the screening of induced chromosomal lesions at very low dosages of chemicals or irradiations, and suggests that X-irradiation does not interfere with the repair process operating with MMS.