D
Daisuke Mikami
Researcher at University of Fukui
Publications - 34
Citations - 459
Daisuke Mikami is an academic researcher from University of Fukui. The author has contributed to research in topics: Kidney & Podocalyxin. The author has an hindex of 10, co-authored 32 publications receiving 297 citations.
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Journal ArticleDOI
Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-α-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells.
Mamiko Kobayashi,Daisuke Mikami,Hideki Kimura,Kazuko Kamiyama,Yukie Morikawa,Seiji Yokoi,Kenji Kasuno,Naoki Takahashi,Takanobu Taniguchi,Masayuki Iwano +9 more
TL;DR: Investigating whether SCFAs activate GPR41 and GPR43, and thereby exert anti-inflammatory effects in human renal cortical epithelial cells (HRCEs) as a main component of kidney tissue suggested that SCFA modification may be a new therapeutic tool for preventing progression of renal inflammation and fibrosis.
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A short-chain fatty acid, propionate, enhances the cytotoxic effect of cisplatin by modulating GPR41 signaling pathways in HepG2 cells
Mamiko Kobayashi,Daisuke Mikami,Junsuke Uwada,Takashi Yazawa,Kazuko Kamiyama,Hideki Kimura,Takanobu Taniguchi,Masayuki Iwano +7 more
TL;DR: The data suggest that a combination of propionate with cisplatin may have better therapeutic effects on HCC compared with conventional treatment, and that a selective GPR41 agonist may be a candidate as an adjuvant therapeutic agent for HCC.
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Cloning of rabbit alpha(1b)-adrenoceptor and pharmacological comparison of alpha(1a)-, alpha(1b)- and alpha(1d)-adrenoceptors in rabbit.
Hai-Lan Piao,Takanobu Taniguchi,Seigo Nakamura,Jun Zhu,Fumiko Suzuki,Daisuke Mikami,Ikunobu Muramatsu +6 more
TL;DR: A high identity of structural and pharmacological profiles of three distinct alpha(1)-adrenoceptor subtypes between rabbit and other species is indicated, but there are species differences in their distribution.
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Telmisartan activates endogenous peroxisome proliferator-activated receptor-δ and may have anti-fibrotic effects in human mesangial cells.
Daisuke Mikami,Hideki Kimura,Kazuko Kamiyama,Kunio Torii,Kenji Kasuno,Naoki Takahashi,Haruyoshi Yoshida,Masayuki Iwano +7 more
TL;DR: It is indicated that in HMC telmisartan activates endogenous PPAR-δ and may prevent TGF-β1-induced fibrotic changes by reducing ERK phosphorylation in a PPARδ-dependent manner, and thus, might be useful for treating hypertensive patients with renal and metabolic disorders.
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β-Hydroxybutyrate enhances the cytotoxic effect of cisplatin via the inhibition of HDAC/survivin axis in human hepatocellular carcinoma cells.
Daisuke Mikami,Mamiko Kobayashi,Junsuke Uwada,Takashi Yazawa,Kazuko Kamiyama,Kazuhisa Nishimori,Yudai Nishikawa,Sho Nishikawa,Seiji Yokoi,Takanobu Taniguchi,Masayuki Iwano +10 more
TL;DR: Investigating whether βOHB enhances cisplatin-induced apoptosis in hepatocellular carcinoma (HCC) cells by modulating activity and/or expression of HDACs found it to be a new adjuvant agent for cisPlatin chemotherapy.