D
Dake Qi
Researcher at University of Manitoba
Publications - 51
Citations - 2110
Dake Qi is an academic researcher from University of Manitoba. The author has contributed to research in topics: Macrophage migration inhibitory factor & AMP-activated protein kinase. The author has an hindex of 24, co-authored 43 publications receiving 1853 citations. Previous affiliations of Dake Qi include Yale University & Shanghai Jiao Tong University.
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Journal ArticleDOI
AMPK: energy sensor and survival mechanism in the ischemic heart
Dake Qi,Lawrence H. Young +1 more
TL;DR: Novel mechanisms of AMPK activation in the ischemic heart, the role of endogenous AM PK activation during ischemia-reperfusion, and the potential therapeutic applications for AMPK-directed therapy are discussed.
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Cardiac macrophage migration inhibitory factor inhibits JNK pathway activation and injury during ischemia/reperfusion
TL;DR: Examining the role of MIF in regulating JNK activation and cardiac injury during experimental ischemia/reperfusion in mouse hearts indicates that endogenous MIF inhibits JNK pathway activation during reperfusion and protects the heart from injury.
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Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism
Dake Qi,Brian Rodrigues +1 more
TL;DR: The action of glucocorticoids, their role in insulin resistance, and their influence in modulating peripheral and cardiac metabolism and heart disease are reviewed.
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A small molecule AMPK activator protects the heart against ischemia-reperfusion injury
Agnes S Kim,Edward J. Miller,Tracy M. Wright,Ji Li,Dake Qi,Kwame Atsina,Vlad G. Zaha,Kei Sakamoto,Lawrence H. Young +8 more
TL;DR: Pre-treatment with A-769662 increased the phosphorylation and inactivation of eukaryotic elongation factor 2 (eEF2), preserved energy charge during ischemia, delayed the development of ischemic contracture, and reduced myocardial apoptosis and necrosis.
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Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion
Sanjoy Ghosh,Thomas Pulinilkunnil,Gloria Yuen,Girish Kewalramani,Ding An,Dake Qi,Ashraf Abrahani,Brian Rodrigues +7 more
TL;DR: It is suggested for the first time that mGSH is crucial for modulating the cell suicide program in short-term diabetic rat hearts.