L
Lin Leng
Researcher at Yale University
Publications - 204
Citations - 13551
Lin Leng is an academic researcher from Yale University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Cytokine. The author has an hindex of 58, co-authored 192 publications receiving 11918 citations. Previous affiliations of Lin Leng include St. John's University & Kaplan Medical Center.
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Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TL;DR: Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.
Journal ArticleDOI
MIF signal transduction initiated by binding to CD74.
Lin Leng,Christine N. Metz,Yan Ju Fang,Jing-Jing Xu,Seamas C. Donnelly,John A. Baugh,Thomas Delohery,Yibang Chen,Robert A. Mitchell,Richard Bucala +9 more
TL;DR: It is reported herein that CD74, a Type II transmembrane protein, is a high-affinity binding protein for MIF, and it is identified as a natural ligand forCD74, which has been implicated previously in signaling and accessory functions for immune cell activation.
Journal ArticleDOI
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.
Xuerong Shi,Lin Leng,Tian Wang,Wenkui Wang,Xin Du,Ji Li,Courtney McDonald,Zun Chen,James W. Murphy,Elias Lolis,Paul W. Noble,Warren Knudson,Richard Bucala +12 more
TL;DR: In this paper, the authors used the CD74-and CD44-deficient COS-7/M6 cell to create stable transfectants expressing CD74, CD44, and a truncated CD44 lacking its intracytoplasmic signaling domain.
Journal ArticleDOI
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
Edward J. Miller,Ji Li,Lin Leng,Courtney McDonald,Toshiya Atsumi,Richard Bucala,Lawrence H. Young +6 more
TL;DR: It is shown that macrophage migration inhibitory factor (MIF), an upstream regulator of inflammation, is released in the ischaemic heart, where it stimulates AMPK activation through CD74, promotes glucose uptake and protects the heart during ischaemia-reperfusion injury.
Journal ArticleDOI
Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity
Hongqi Lue,Michael Thiele,J Franz,Edgar Dahl,Stefanie Speckgens,Lin Leng,Gunter Fingerle-Rowson,R Bucala,Bernhard Lüscher,Jürgen Bernhagen +9 more
TL;DR: MIF can directly promote cell survival through activation of the PI3K/Akt pathway and this effect is critical for tumor cell survival.