Showing papers by "Dale C. Snover published in 2005"
Dartmouth–Hitchcock Medical Center1, Veterans Health Administration2, Dartmouth College3, University of North Carolina at Chapel Hill4, University of Colorado Denver5, University of Southern California6, Cleveland Clinic7, University of Texas MD Anderson Cancer Center8, University of Toronto9, Emory University10, University of Minnesota11, University of Iowa12
TL;DR: CRC is diagnosed in a clinically important proportion of patients following complete colonoscopy and polypectomy and risk factors for CRC and adenoma with high-grade dysplasia are examined.
455 citations
TL;DR: The results strongly support the practice of performing FISH in all cases with immunohistochemical scores of 2+, particularly in routine practice, in which interobserver variability in immunohistsochemical scoring among multiple pathologists is likely to be high.
Abstract: Because HER-2 expression in invasive carcinoma of the breast has well-documented ramifications for treatment and prognosis, accurate assessment of HER-2 status is critical. Comparative studies have shown high concordance rates between immunohistochemical analysis and fluorescence in situ hybridization (FISH) in cases with immunohistochemical scores of 0 or 1+ (negative) and 3+ (strongly positive) and low concordance rates among cases with immunohistochemical scores of 2+. The present study was performed to determine concordance rates in a setting more representative of routine clinical practice, in which multiple pathologists submit specimens to a single cytogenetics referral laboratory. We found a higher rate of discordance between immunohistochemical analysis and FISH (approximately 92%) in the groups with immunohistochemical scores of 2+ than reported in other studies. These results strongly support the practice of performing FISH in all cases with immunohistochemical scores of 2+, particularly in routine practice, in which interobserver variability in immunohistochemical scoring among multiple pathologists is likely to be high.
45 citations
TL;DR: This review will present the histological classification of serrated polyps of the large intestine, relate thathistological classification to molecular aspects of the lesions, and present recommendations for management.
41 citations
4 citations
3 citations