Dale R. Taylor

TL;DR: It is shown that the death of haemopoietic precursor cells on withdrawal of the relevant CSF is due to active cell death5, or apoptosis, indicating that CSFs promote cell survival by suppression of the process of apoptosis.

TL;DR: Immunoglobulin variable region gene sequencing, and 5-bromo-2′-deoxyuridine pulse–chase studies indicate that long-lived splenic plasma cells are a mixture of cells derived from the extrafollicular and germinal center responses and cellsderived from virgin and memory B cells.

TL;DR: It is shown that a Th2 response to hapten–protein can proceed in a node where there is substantial Th1 activity, indicating that the Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone.

TL;DR: It is argued that Ig class switching at this time, which is associated with cognate T cell-B cell interaction in the T zone, has a major impact on the class and subclasses of Ig produced during the response.

TL;DR: It is concluded that efficient activation of hypermutation depends on interaction with T cells, but some hypermutations may be induced without such signals, even outside germinal centers.