S
Sanjiv A. Luther
Researcher at University of Lausanne
Publications - 97
Citations - 11478
Sanjiv A. Luther is an academic researcher from University of Lausanne. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 44, co-authored 87 publications receiving 9950 citations. Previous affiliations of Sanjiv A. Luther include University of California, San Francisco & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
A chemokine-driven positive feedback loop organizes lymphoid follicles
K M Ansel,Vu N. Ngo,P. L. Hyman,Sanjiv A. Luther,Reinhold Förster,Jonathon D. Sedgwick,Jeffrey L. Browning,Martin Lipp,Jason G. Cyster +8 more
TL;DR: It is established that B-lymphocyte chemoattractant (BLC/BCA1) and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen, and that BLC is required for the development of most lymph nodes and Peyer's patches.
Journal ArticleDOI
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.
Alexander Link,Tobias K. Vogt,Stéphanie Favre,Mirjam R. Britschgi,Hans Acha-Orbea,Boris Hinz,Jason G. Cyster,Sanjiv A. Luther +7 more
TL;DR: It is suggested that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4+ and CD8+ T cell homeostasis by providing a limited reservoir of survival factors.
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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.
Imran Siddiqui,Karin Schaeuble,Vijaykumar Chennupati,Silvia A. Fuertes Marraco,Sandra Calderon-Copete,Daniela Pais Ferreira,Santiago J. Carmona,Santiago J. Carmona,Santiago J. Carmona,Leonardo Scarpellino,David Gfeller,David Gfeller,David Gfeller,Sylvain Pradervand,Sanjiv A. Luther,Daniel E. Speiser,Werner Held +16 more
TL;DR: This work identified a subset of tumor‐reactive TILs bearing hallmarks of exhausted cells and central memory cells, including expression of the checkpoint protein PD‐1 and the transcription factor Tcf1 that promote tumor control in response to vaccination and checkpoint blockade immunotherapy.
Journal ArticleDOI
Chemokines as regulators of T cell differentiation
Sanjiv A. Luther,Jason G. Cyster +1 more
TL;DR: Findings in the CCL2- CCR2 and CCL3-CCR5 ligand-receptor systems are focused on and models to account for the action of chemokines and G protein–coupled receptor signals in regulating T cell differentiation are discussed.
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Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.
TL;DR: It is proposed that ELC- and SLC-expressing T zone stromal cells play a central role in bringing naive T cells and DCs together for the initiation of immune responses.