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Damu Tang
Researcher at McMaster University
Publications - 132
Citations - 6381
Damu Tang is an academic researcher from McMaster University. The author has contributed to research in topics: Prostate cancer & Apoptosis. The author has an hindex of 39, co-authored 125 publications receiving 5728 citations. Previous affiliations of Damu Tang include McMaster-Carr & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus
TL;DR: The emerging picture is one in which early viral transcripts trigger PKR phosphorylated in untransformed cells, which in turn leads to inhibition of translation of viral genes; this phosphorylation event is blocked by an element(s) in the Ras pathway in the transformed cells, allowing viral protein synthesis to ensue.
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ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53
Damu Tang,Dongcheng Wu,Atsushi Hirao,Jill M. Lahti,Lieqi Liu,Brie Mazza,Vincent J. Kidd,Tak W. Mak,Alistair J. Ingram +8 more
TL;DR: Results indicate that DNA damage activates parallel ERK and p53 pathways in an ATM-dependent manner and these pathways might function cooperatively in cell cycle arrest and apoptosis.
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An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator
Damu Tang,Jeffery Yeung,Ki-Young Lee,Masayuki Matsushita,Hideki Matsui,Kazuhito Tomizawa,Osamu Hatase,Jerry H. Wang +7 more
TL;DR: A distinct clone encoding a 39-kDa isoform of Nck5a shares many common characteristics with p35, including Ckd5 activating activity and brain- and neuron-specific expression, suggesting that they define a new family of cyclin-dependent kinase-activating proteins.
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PKM2 contributes to cancer metabolism.
TL;DR: The current understanding of PKM2 in regulating cancer metabolism is discussed and it is discussed how the dimer promotes aerobic glycolysis by modulating transcriptional regulation and the tetramer promotes glucose-derived carbs for ATP production via oxidative phosphorylation.
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Caspase-8 Activation and Bid Cleavage Contribute to MCF7 Cellular Execution in a Caspase-3-dependent Manner during Staurosporine-mediated Apoptosis
TL;DR: Evidence is provided that activation of caspase-8, and subsequent Bid cleavage, does indeed participate in cytochrome c-mediated apoptosis, at least in certain circumstances and cell types and it is found that it greatly shortens the execution time.