D
Dan Lou
Researcher at Johns Hopkins University
Publications - 25
Citations - 384
Dan Lou is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 9, co-authored 25 publications receiving 283 citations. Previous affiliations of Dan Lou include Centers for Disease Control and Prevention & Fudan University.
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Journal ArticleDOI
Crosstalk of Genetic Variants, Allele-Specific DNA Methylation, and Environmental Factors for Complex Disease Risk.
TL;DR: A working model is proposed that the small effect of a SNP acts through altered ABTF and/or ASM, for ASE and eventual disease outcome (named as a “SNP intensifier” model).
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Paraquat inhibits cell viability via enhanced oxidative stress and apoptosis in human neural progenitor cells.
TL;DR: It is shown that PQ treatment reduces the cell viability and proliferation and induces reactive oxygen species (ROS) production in a dose-dependent manner and apoptosis induced by PQ was significantly increased at a concentration of as low as 1 μM.
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Nrf2/ARE Pathway Involved in Oxidative Stress Induced by Paraquat in Human Neural Progenitor Cells.
Tingting Dou,Mengling Yan,Xinjin Wang,Wen Lu,Lina Zhao,Dan Lou,Chunhua Wu,Xiuli Chang,Zhijun Zhou +8 more
TL;DR: It is shown that PQ can decrease the activity of SOD and CAT but increase MDA and LDH level and the results suggested that Nrf2/ARE pathway is involved in mild to moderate PQ-induced oxidative stress which is evident from dampened NRF2 activity and low expression of antioxidant genes in PQ induced oxidative damage.
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Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism.
TL;DR: Results demonstrated that the mutation of both hop‐1 and pink‐1 reduced the vulnerability of lethal, behavioral, and mitochondrial toxicity induced by RO/PQ, suggesting that presenilin and PINK1 play important roles in the RO/ PQ‐induced neurotoxicity through the mechanisms involved in mitochondria‐associated membranes.
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Highly specific and sensitive detection of bisphenol A in water samples using an enzyme-linked immunosorbent assay employing a novel synthetic antigen
TL;DR: The method established in this study is an easy, rapid and specific method used for the quantitative detection of bisphenol A in water samples and had a low cross-reaction with other steroid substances.