Daniel A. Lawrence

TL;DR: It is reported that vitronectin significantly enhances the migration of smooth muscle cells (SMCs), and that the specific VNR αvβ3 is required for cell motility, and that PAI-1 can control cell–matrix interactions by regulating the accessibility of specific cell-attachment sites.

TL;DR: It is demonstrated that tPA is both necessary and sufficient to directly increase vascular permeability in the early stages of BBB opening, and suggested that this occurs through a receptor-mediated cell signaling event and not through generalized degradation of the vascular basement membrane.

TL;DR: Results indicate that cultured bovine aortic endothelial cells synthesize and secrete a protein which inhibits plasminogen activators and is distinct from protease nexin, a major endothelial cell product, and, as such, probably plays an important role in regulating the fibrinolytic system of these cells.

TL;DR: It is demonstrated that PDGF signaling regulates blood-brain barrier permeability and suggest potential new strategies for stroke treatment through activation of PDGF-α receptors on perivascular astrocytes.

TL;DR: A lambda gt11 expression library containing cDNA inserts prepared from human placental mRNA was screened immunologically using an antibody probe developed against the beta-migrating plasminogen activator inhibitor (beta-PAI) purified from cultured bovine aortic endothelial cells, indicating that the beta -PAI is a member of the serine proteinase inhibitor (serpin) superfamily.