D
Daniel Alagille
Researcher at French Institute of Health and Medical Research
Publications - 70
Citations - 4469
Daniel Alagille is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cholestasis & Hepatitis. The author has an hindex of 35, co-authored 70 publications receiving 4335 citations. Previous affiliations of Daniel Alagille include University of Paris-Sud & University of Pavia.
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Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur.
TL;DR: Among 30 children with hepatic ductular hypoplasia and normal extrahepatic bile ducts, 15 formed a hemogeneous, readily recognizable group that has characteristic facies, a mesosystolic murmur, vertebral arch defects, growth retardation, mental retardation and hypogonadism.
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Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): Review of 80 cases
TL;DR: Patients with syndromic PILBD consisted of supplementation of medium-chain triglycerides and fat-soluble vitamins and administration of cholestyramine or phenobarbital, and an autosomal dominant mode of transmission, with variable penetrance, seems likely.
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Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: A second type of “autoimmune” hepatitis
Jean-Claude Homberg,Nisen Abuaf,Olivier Bernard,Shamsul Islam,Fernando Alvarez,Samir H. Khalil,Raoul Poupon,Darnis F,Victor-Georges Lévy,P. Grippon,Pierre Opolon,Jacques Bernuau,Jean-Pierre Benhamou,Daniel Alagille +13 more
TL;DR: Sixty‐five patients with histologically proven chronic active hepatitis of unknown cause but associated with the antiliver/kidney microsome antibody type 1, confirmed by immunofluorescence and immunoprecipitation, were selected as forming a special entity.
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Portal obstruction in children. I. Clinical investigation and hemorrhage risk
Fernando Alvarez,Olivier Bernard,Francis Brunelle,P. Hadchouel,Michel Odièvre,Daniel Alagille +5 more
TL;DR: Angiography should be limited to children with a history of gastrointestinal tract bleeding for whom a surgical portosystemic shunt is being considered, and the presence of tense varices and congestion of esophageal mucosa clearly augmented the risk of bleeding.
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Autoimmune Hepatitis Associated with Anti-actin Antibodies in Children and Adolescents
Giuseppe Maggiore,Florence Veber,Olivier Bernard,Michelle Hadchouel,Jean Claude Homberg,Fernando Alvarez,P. Hadchouel,Daniel Alagille +7 more
TL;DR: A group of autoimmune hepatitis in children characterized by the presence of serum anti-actin antibodies is defined and indications that immunosuppressive therapy improves liver function are indicated, which suggest that progressive liver failure may occur in early adulthood and may require liver transplantation.