M
Michelle Hadchouel
Researcher at French Institute of Health and Medical Research
Publications - 129
Citations - 10311
Michelle Hadchouel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Alagille syndrome & Cholestasis. The author has an hindex of 51, co-authored 129 publications receiving 9910 citations. Previous affiliations of Michelle Hadchouel include University of Pavia & Centre national de la recherche scientifique.
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Journal ArticleDOI
Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
J. M. L. De Vree,Emmanuel Jacquemin,Ekkehard Sturm,Danièle Cresteil,Piter J. Bosma,Jan Aten,Jean-François Deleuze,M. Desrochers,Martin Burdelski,Olivier Bernard,R. P. J. Oude Elferink,Michelle Hadchouel +11 more
TL;DR: The results demonstrate that mutations in the human MDR3 gene lead to progressive familial intrahepatic cholestasis with high serum gamma-GT.
Journal ArticleDOI
Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
Marco Pontoglio,J. Barra,Michelle Hadchouel,Antonia Doyen,Chantal Kress,Joséphine Poggi Bach,Charles Babinet,Moshe Yaniv +7 more
TL;DR: HNF1 is a transcriptional activator of many hepatic genes including albumin, alpha1-antitrypsin, and alpha- and beta-fibrinogen, and it is predominantly expressed in liver and kidney.
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Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): Review of 80 cases
TL;DR: Patients with syndromic PILBD consisted of supplementation of medium-chain triglycerides and fat-soluble vitamins and administration of cholestyramine or phenobarbital, and an autosomal dominant mode of transmission, with variable penetrance, seems likely.
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Detection of hepatitis B virus DNA in serum by a simple spot hybridization technique: comparison with results for other viral markers.
Jacques Scotto,Jacques Scotto,Michelle Hadchouel,Christiane Hery,Jeannine Yvart,Pierre Tiollais,Christian Brechot +6 more
TL;DR: A simplified spot method for determination in serum of hepatitis B virus DNA (HBV DNA) by molecular hybridization is proposed, which greatly reduced the duration of the steps preceding hybridization proper and allowed more sensitive detection in samples of only 25 or 50 m̈1.
Journal ArticleDOI
The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood☆☆☆
Emmanuel Jacquemin,Olivier Bernard,Michelle Hadchouel,Danièle Cresteil,J.Marleen L. De Vree,Marianne Paul,Ronald P.J. Oude Elferink,Piter J. Bosma,Etienne Sokal,Ekkehard Sturm,Martin Burdelski,M. Dumont,George L. Scheffer +12 more
TL;DR: At least one third of the patients with a progressive familial intrahepatic cholestasis type 3 phenotype have a proven defect of the multidrug resistance 3 gene (MDR3), which should also be considered in adult liver diseases.