D
Daniel Irimia
Researcher at Harvard University
Publications - 206
Citations - 21314
Daniel Irimia is an academic researcher from Harvard University. The author has contributed to research in topics: Chemotaxis & Neutrophil extracellular traps. The author has an hindex of 62, co-authored 192 publications receiving 18867 citations. Previous affiliations of Daniel Irimia include University of Illinois at Chicago & Pacific Northwest National Laboratory.
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Journal ArticleDOI
Isolation of rare circulating tumour cells in cancer patients by microchip technology.
Sunitha Nagrath,Lecia V. Sequist,Shyamala Maheswaran,Daphne W. Bell,Daphne W. Bell,Daniel Irimia,Lindsey Ulkus,Matthew R. Smith,Eunice L. Kwak,Subba R. Digumarthy,Alona Muzikansky,Paula D. Ryan,Ulysses J. Balis,Ulysses J. Balis,Ronald G. Tompkins,Daniel A. Haber,Mehmet Toner +16 more
TL;DR: The CTC-chip successfully identified CTCs in the peripheral blood of patients with metastatic lung, prostate, pancreatic, breast and colon cancer in 115 of 116 samples, with a range of 5–1,281CTCs per ml and approximately 50% purity.
Journal ArticleDOI
Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Shyamala Maheswaran,Lecia V. Sequist,Sunitha Nagrath,Lindsey Ulkus,Brian W. Brannigan,Chey V. Collura,Elizabeth J. Inserra,Sven Diederichs,A. John Iafrate,Daphne W. Bell,Subba R. Digumarthy,Alona Muzikansky,Alona Muzikansky,Daniel Irimia,Jeffrey Settleman,Ronald G. Tompkins,Ronald G. Tompkins,Thomas J. Lynch,Mehmet Toner,Mehmet Toner,Daniel A. Haber,Daniel A. Haber +21 more
TL;DR: Molecular analysis of circulating tumor cells from the blood of patients with lung cancer offers the possibility of monitoring changes in epithelial tumor genotypes during the course of treatment, and shows that a reduction in the number of captured cells was associated with a radiographic tumor response; an increase in theNumber of cells wasassociated with tumor progression, with the emergence of additional EGFR mutations in some cases.
Journal ArticleDOI
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Shannon L. Stott,Chia-Hsien Hsu,Chia-Hsien Hsu,Chia-Hsien Hsu,Dina Tsukrov,Min Yu,David T. Miyamoto,Belinda A. Waltman,S. Michael Rothenberg,Ajay Shah,Malgorzata E. Smas,George K. Korir,Frederick P. Floyd,Anna J. Gilman,Jenna B. Lord,Daniel Winokur,Simeon Springer,Daniel Irimia,Daniel Irimia,Sunitha Nagrath,Sunitha Nagrath,Lecia V. Sequist,Lecia V. Sequist,Richard T. Lee,Richard T. Lee,Kurt J. Isselbacher,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Mehmet Toner,Mehmet Toner +30 more
TL;DR: A high-throughput microfluidic mixing device, the herringbone-chip, or “HB-Chip,” is described, which provides an enhanced platform for CTC isolation and reveals microclusters of CTCs, previously unappreciated tumor cell aggregates that may contribute to the hematogenous dissemination of cancer.
Journal ArticleDOI
Continuous inertial focusing, ordering, and separation of particles in microchannels
TL;DR: The ability to differentially order particles of different sizes, continuously, at high rates, and without external forces in microchannels is expected to have a broad range of applications in continuous bioparticle separation, high-throughput cytometry, and large-scale filtration systems.
Journal ArticleDOI
Blood-on-a-Chip
Mehmet Toner,Daniel Irimia +1 more
TL;DR: Some of the emerging principles for manipulating blood cells at microscale and promising high-throughput approaches to blood cell separation using microdevices are reviewed.