M
Min Yu
Researcher at University of Southern California
Publications - 62
Citations - 12670
Min Yu is an academic researcher from University of Southern California. The author has contributed to research in topics: Circulating tumor cell & Metastasis. The author has an hindex of 30, co-authored 58 publications receiving 10853 citations. Previous affiliations of Min Yu include Harvard University & Memorial Sloan Kettering Cancer Center.
Papers
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Journal ArticleDOI
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
Journal ArticleDOI
Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis
Nicola Aceto,Aditya Bardia,David T. Miyamoto,Maria C. Donaldson,Ben S. Wittner,Joel A. Spencer,Min Yu,Adam Pely,Amanda Engstrom,Huili Zhu,Brian W. Brannigan,Ravi Kapur,Shannon L. Stott,Toshi Shioda,Sridhar Ramaswamy,David T. Ting,Charles P. Lin,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: Using mouse models with tagged mammary tumors, it is demonstrated that CTC clusters arise from oligoclonal tumor cell groupings and not from intravascular aggregation events, and though rare in the circulation, they greatly contribute to the metastatic spread of cancer.
Journal ArticleDOI
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Shannon L. Stott,Chia-Hsien Hsu,Chia-Hsien Hsu,Chia-Hsien Hsu,Dina Tsukrov,Min Yu,David T. Miyamoto,Belinda A. Waltman,S. Michael Rothenberg,Ajay Shah,Malgorzata E. Smas,George K. Korir,Frederick P. Floyd,Anna J. Gilman,Jenna B. Lord,Daniel Winokur,Simeon Springer,Daniel Irimia,Daniel Irimia,Sunitha Nagrath,Sunitha Nagrath,Lecia V. Sequist,Lecia V. Sequist,Richard T. Lee,Richard T. Lee,Kurt J. Isselbacher,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Mehmet Toner,Mehmet Toner +30 more
TL;DR: A high-throughput microfluidic mixing device, the herringbone-chip, or “HB-Chip,” is described, which provides an enhanced platform for CTC isolation and reveals microclusters of CTCs, previously unappreciated tumor cell aggregates that may contribute to the hematogenous dissemination of cancer.
Journal ArticleDOI
Circulating tumor cells: approaches to isolation and characterization
TL;DR: Improvements in technologies to yield purer CTC populations amenable to better cellular and molecular characterization will enable a broad range of clinical applications, including early detection of disease and the discovery of biomarkers to predict treatment responses and disease progression.
Journal ArticleDOI
Inertial Focusing for Tumor Antigen–Dependent and –Independent Sorting of Rare Circulating Tumor Cells
Emre Ozkumur,Ajay Shah,Jordan C. Ciciliano,Benjamin L. Emmink,David T. Miyamoto,Elena F. Brachtel,Min Yu,Min Yu,Pin-i Chen,Bailey Morgan,Julie Trautwein,Anya Kimura,Sudarshana Sengupta,Shannon L. Stott,Nezihi Murat Karabacak,Tom Barber,John R. Walsh,Kyle C. Smith,Philipp S. Spuhler,James P. Sullivan,Richard T. Lee,David T. Ting,Xi Luo,Xi Luo,Alice T. Shaw,Aditya Bardia,Lecia V. Sequist,David N. Louis,Shyamala Maheswaran,Ravi Kapur,Daniel A. Haber,Daniel A. Haber,Mehmet Toner +32 more
TL;DR: A multistage microfluidic device that is capable of sorting rare circulating tumor cells (CTCs) that are either positive or negative for the surface antigen epithelial cell adhesion molecule (EpCAM) and could be a promising addition to current diagnostic tools used in the clinic is developed.