D
Daniel John Torrey
Publications - 3
Citations - 228
Daniel John Torrey is an academic researcher. The author has contributed to research in topics: MG132 & Ischemic preconditioning. The author has an hindex of 3, co-authored 3 publications receiving 213 citations.
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Journal ArticleDOI
Rapid Degradation of Bim by the Ubiquitin-Proteasome Pathway Mediates Short-term Ischemic Tolerance in Cultured Neurons
Robert Meller,Jennifer A. Cameron,Daniel John Torrey,Corrin Erin Clayton,Andrea Nicole Ordonez,David C. Henshall,Manabu Minami,Clara K. Schindler,Julie A. Saugstad,Roger P. Simon +9 more
TL;DR: The results suggest that following preconditioning ischemia, Bim is rapidly degraded by the ubiquitin-proteasome system, resulting in rapid ischemic tolerance, which suggests that the rapid degradation of cell death-promoting proteins by the proteasome pathway may represent a novel therapeutic strategy to reduce cell damage following neuropathological insults, e.g. stroke.
Journal ArticleDOI
Ubiquitin proteasome-mediated synaptic reorganization: a novel mechanism underlying rapid ischemic tolerance.
Robert Meller,Simon Thompson,Theresa A. Lusardi,Andrea Nicole Ordonez,Michelle D Ashley,Veronica J Jessick,Weihzen Wang,Daniel John Torrey,David C. Henshall,Philip R. Gafken,Julie A. Saugstad,Zhi-Gang Xiong,Roger P. Simon +12 more
TL;DR: Together these data suggest that rapid tolerance results from changes to the postsynaptic density mediated by the ubiquitin–proteasome system, rendering neurons resistant to excitotoxicity.
Journal ArticleDOI
Activation of the caspase 8 pathway mediates seizure-induced cell death in cultured hippocampal neurons
Robert Meller,Corrin Erin Clayton,Daniel John Torrey,Clara K. Schindler,J.Q. Lan,Jennifer A. Cameron,Xiang-Ping Chu,Z.G. Xiong,Roger P. Simon,David C. Henshall +9 more
TL;DR: The data suggests the extrinsic cell death pathway-associated caspase 8 is activated following seizures in vitro, which suggests multiple glutamate receptors regulate seizure-induced cell death.