Philip R. Gafken

TL;DR: DOT1 was originally identified as a gene affecting telomeric silencing in S. cerevisiae, but it is found that Dot1p methylates histone H3 on lysine 79, which maps to the top and bottom of the nucleosome core.

TL;DR: It is proposed that histone modifications are tied to the alternative nucleosome assembly pathways that use primarily H3 at replication forks and H3.3 at actively transcribed genes in a replication-independent manner.

TL;DR: This study provides the first evidence for regulation of global chromatin structure by an oncoprotein and may explain the broad effects of Myc on cell behavior and tumorigenesis.

TL;DR: The analytical performance of a biomarker identification pipeline based on targeted mass spectrometry would be sufficient for data-dependent prioritization of candidate biomarkers, de novo development of assays and multiplexed biomarker verification and should support the use of an analogous approach with human samples.

TL;DR: It is discovered that acetylation of histone H3 and H4 is dynamically regulated around an origin of replication, at the level of multiply acetylated histones, and it is found that this acetylations is required for efficient origin activation during S phase.