D
Daniel Jun
Researcher at University of Defence
Publications - 291
Citations - 6250
Daniel Jun is an academic researcher from University of Defence. The author has contributed to research in topics: Nerve agent & Acetylcholinesterase. The author has an hindex of 37, co-authored 287 publications receiving 5505 citations. Previous affiliations of Daniel Jun include Military Academy & Military Medical Academy.
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Journal ArticleDOI
Condensed and hydrolysable tannins as antioxidants influencing the health.
Vit Koleckar,Katerina Kubikova,Zuzana Rehakova,Kamil Kuca,Daniel Jun,Ludek Jahodar,Lubomír Opletal +6 more
TL;DR: This review offers a general description of chemistry of both hydrolysable and condensed tannins (proanthocyanidins), the mechanisms of their antioxidation action, like free radical scavenging activity, chelation of transition metals, inhibition of prooxidative enzymes and lipid peroxidation.
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Structural requirements of acetylcholinesterase reactivators.
TL;DR: The relationship between chemical structure of AChE reactivators and their ability to reactivate A cholinergic nervous system inhibited by several nerve agents and pesticides is summarized and it is shown that there are several structural fragments possibly involving in the structure of proposed A ChE reactsivators.
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Treatment of Organophosphate Intoxication Using Cholinesterase Reactivators:Facts and Fiction
TL;DR: Reactivation of cholinesterases in the peripheral and central nervous system is described and it is underlined its importance for the survival or death of the organism poisoned with OP.
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In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.
Maja Čalić,Ana Lucić Vrdoljak,Božica Radić,Dubravko Jelić,Daniel Jun,Kamil Kuca,Zrinka Kovarik +6 more
TL;DR: The potency of the oximes K048 and K027 to protect mice from five-fold LD50 oftabun and their low toxicity make these compounds leading in the therapy of tabun poisoning.
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Phosphatidylinositol 3-Kinase (PI3K) and Phosphatidylinositol 3-Kinase-Related Kinase (PIKK) Inhibitors: Importance of the Morpholine Ring
TL;DR: While several PI3K pathway inhibitors have recently shown promising clinical responses, inhibitors of the DNA damage-related PIKKs remain thus far largely in preclinical development.